DR. THOMAS F. KELLY JR., M.D., P.A.

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This study focused on improving how quickly patients with urgent urology needs can see a doctor. Before the changes, patients waited an average of 59 days for an appointment, but after implementing new strategies, that wait time dropped to about 22 days, and the number of patients seen within 10 days increased from 3 to 8 per week. These improvements are important because timely access to care can significantly affect patient outcomes and satisfaction. Who this helps: This helps patients with urgent urology issues.

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This study revisits an event from 1954 where a woman named Dorothy Martin predicted a catastrophic flood that would be avoided by her followers being rescued by aliens. Contrary to earlier claims that the group became more devoted and continued to recruit after the prophecy failed, new evidence shows they actually stopped believing and lost interest quickly. The researchers also engaged in unethical behavior, including falsifying messages and manipulating events, raising serious concerns about the integrity of their original findings. Who this helps: This helps researchers, ethicists, and those interested in psychology and the integrity of scientific research.

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This study looked at the use and payment rates for foot and ankle surgeries, specifically total ankle replacements and fusion procedures, from 2007 to 2025. It found that while the number of surgeries increased significantly—some by over 500%—the money doctors are paid for these procedures dropped between 34% and 37% when adjusted for inflation. This is important because it highlights that even as more patients are getting these surgeries, doctors are being paid less for their work, which could affect access and quality of care. Who this helps: Patients needing foot and ankle surgeries.

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This study looked at how sleep duration affects cholesterol and fat levels in the body by analyzing data from over 732,000 participants. Researchers found 17 new genetic locations linked to lipid changes due to short or long sleep, suggesting that people who sleep too little or too much may have higher cholesterol and fat levels that contribute to heart disease. These findings could lead to new treatments for cholesterol problems, especially for those who struggle with sleep. Who this helps: This helps patients with sleep issues and related cardiovascular conditions.

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This study looked at how hormone replacement therapy (HRT) can help manage mental health problems that women may experience during menopause, such as depression and anxiety. It found that estrogen therapy, especially in patch form, might help reduce these mental health symptoms in women nearing menopause, but the benefits for women after menopause aren’t as clear. The research highlights that starting HRT sooner after menopause may be more beneficial for brain health, while waiting longer could increase dementia risk, indicating that treatment needs to be tailored to each woman's situation. Who this helps: This information helps women experiencing menopause and their doctors in making informed decisions about mental health treatment.

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This study looked at how exposure to heavy metals might affect the worsening of chronic kidney disease (CKD) in patients. Researchers analyzed nail clippings and blood samples from 20 people, finding that those with rapidly progressing CKD had higher levels of heavy metals (293 micrograms per gram) compared to those with stable CKD (267 micrograms per gram). Although the differences were not statistically significant, the findings highlight the need to investigate how environmental factors like heavy metal exposure could influence CKD. Who this helps: This helps patients with chronic kidney disease and their healthcare providers.

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Researchers studied the impact of a gene called HKDC1 on aging and memory loss in both mice and humans. They found that levels of HKDC1 decreased in people with cognitive decline and in older mice, leading to anxiety, memory issues, and inflammation in the brain. Understanding HKDC1's role in neurodegeneration is crucial because it could help develop new treatments for age-related cognitive disorders like Alzheimer's disease. Who this helps: This benefits patients experiencing cognitive decline and their families.

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This study focused on understanding the role of a protein called Class A scavenger receptor (SR-A) in breast cancer and how it affects certain immune cells, known as tumor-associated macrophages (TAMs). Researchers found that mice without SR-A developed tumors more slowly and had fewer instances of cancer spreading to the lungs compared to those with SR-A, suggesting that SR-A helps tumors grow and spread. These findings are important because they highlight a specific target for improving breast cancer treatment by potentially blocking SR-A's effects. Who this helps: This helps patients with breast cancer by identifying a new target for therapy.

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This study looked at how physical activity levels and sitting time affected pain in middle-aged and older adults with musculoskeletal pain. Researchers found that spending more time sitting increased pain levels, especially for those who usually experience higher pain. Conversely, those who were less afraid of movement found that more physical activity eased their pain, while those who feared movement did not experience this benefit. Who this helps: This research benefits older adults with chronic pain and their healthcare providers.

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Researchers studied the effects of a treatment combining a cytokine therapy (IRX-2) with a drug called pembrolizumab before chemotherapy in patients with triple-negative breast cancer (TNBC). They found that this combination led to significant tumor reduction and immune system activation, with a high rate of patients achieving complete tumor response after treatment. This is important because it shows a promising new approach to improve outcomes for patients with a challenging type of breast cancer. Who this helps: This benefits patients with triple-negative breast cancer.

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This study looked at how different local chicken breeds in Tanzania produce eggs. It found that, on average, the chickens laid about 52 eggs each year, with an average egg weight of 43 grams. Notably, the Kuchi chickens laid the heaviest eggs and had shorter breaks between laying clutches. These findings are important because improving egg production can help local farmers increase food security and income. Who this helps: This helps local farmers and communities that rely on chicken farming for their livelihoods.

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This study looked at how the type of suture material used during a cervical cerclage can affect bacterial growth related to pregnancy complications. The researchers found that braided sutures allowed more Gardnerella bacteria to form biofilms—over 10 times more than monofilament sutures. This is important because it suggests that using braided sutures may lead to higher rates of infections and complications like preterm birth in pregnant individuals. Who this helps: This helps pregnant patients at risk of cervical issues and their healthcare providers.

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This study looked at how certain genes interact with alcohol consumption to affect blood pressure in over 1.1 million people from different backgrounds. Researchers found 46 specific genetic locations that affect blood pressure related to alcohol use, revealing that the impact of one genetic factor (BRAP) on blood pressure is about six times greater in people who drink than in those who don’t. Understanding these genetic interactions can help in developing better strategies to manage high blood pressure, especially among drinkers. Who this helps: This information benefits patients with high blood pressure and their doctors by providing insights into personalized treatment options.

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This study focused on creating and testing a new assessment tool for ambulance staff to use when treating pregnant or recently pregnant women. Researchers found that using their new tool helped identify serious issues in 251 patient cases that might have gone unnoticed with existing methods, highlighting many abnormal signs that require urgent attention. This matters because ensuring timely and accurate assessment of perinatal patients can lead to better health outcomes for mothers and babies. Who this helps: This helps patients, particularly pregnant women and new mothers.

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This study focused on analyzing a large collection of over 480,000 user reviews from health apps to better understand privacy and trust concerns among users. The researchers classified these reviews into seven categories, revealing important insights into how users feel about the privacy of their health information and their trust in both the apps and their healthcare providers. By making this dataset publicly available, the researchers aim to help future studies improve the safety and reliability of health apps. Who this helps: Patients and developers of health applications.

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This study looked at why elective orthopedic surgeries are canceled less than a day before they are scheduled, focusing on factors related to patients, surgeons, and the healthcare system. It found that 40% of cancellations were due to patient issues—like not following prep instructions, lack of transportation, or needing medical clearance—while surgery or administration-related problems accounted for the rest. Reducing these last-minute cancellations could improve surgical schedules and patient care. Who this helps: This helps patients waiting for surgery and healthcare providers managing surgical schedules.

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This study looked at various systems around the world where communities track health data related to people, animals, and the environment. Researchers gathered information from 38 out of 60 active systems, creating a detailed list of health data parameters, showing that many systems (29%) collect information from multiple sectors, while 45% focus only on human health. This is important because it highlights the differences in how health data is collected, which can help improve future systems and responses during disease outbreaks. Who this helps: This helps public health officials and researchers by providing a guide to better data sharing and understanding of health trends across different sectors.

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This study developed a new model called T5ProtChem that can analyze both molecular and protein sequences at the same time, which has not been done effectively before. The model showed outstanding results, achieving the best performance to date in predicting how well proteins bind to chemicals and other reactions, making it useful for tasks like classifying chemical binders and predicting how molecules interact. This is important because it can significantly improve drug discovery and protein engineering processes. Who this helps: This helps researchers in drug discovery and biotechnology.

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This study looked at how state laws that let pharmacists provide pre-exposure prophylaxis (PrEP) for HIV affect its usage. The researchers found that when pharmacists are allowed to prescribe PrEP indefinitely, there is an increase of 25 users per 100,000 people, which is about 14% of the average PrEP usage in 2023. This matters because making PrEP more accessible can help prevent the spread of HIV and improve public health. Who this helps: Patients at risk for HIV and public health programs.

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This study looked at how well doctors can collect and analyze circulating tumor cells (CTCs) from blood samples in patients with rare types of epithelial ovarian cancer. Researchers found CTCs in 45% of blood samples from regular veins and 55% from ovarian veins, with some ovarian samples showing as many as 4,776 CTCs. The results suggest that patients with CTCs in their blood had a higher risk of death, indicating that tracking these cells could help predict cancer outcomes. Who this helps: This benefits patients with rare ovarian cancer and their doctors by providing a potential method for monitoring disease progression.

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This study looked at why people from Black African Diaspora Communities (BAFDC) are often left out of health and care research, even though they face worse health outcomes. The researchers reviewed 43 documents and identified 8 main ways (called initial programme theories) that explain why this group is underrepresented, including issues like a lack of trust in the research system and biases against them. Understanding these barriers is important because it can inform strategies to improve the participation of BAFDC in health research, ultimately leading to better healthcare outcomes for these communities. Who this helps: This helps patients from Black African Diaspora Communities and the healthcare professionals working with them.

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This study looked at how middle-management staff in maternity and neonatal services help create safe environments for patients. Researchers interviewed 36 leaders in English healthcare facilities and found that these middle managers play a crucial role in promoting safety by connecting different teams, listening to patient feedback, and navigating between policies and everyday practices. This matters because strong safety cultures can reduce the chances of healthcare errors and improve patient outcomes. Who this helps: This helps patients and healthcare providers by enhancing safety in maternity and neonatal care.

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This study looked at how well mental health nurses in Victoria, Australia, felt about the support they received when implementing clinical supervision, which helps improve their wellbeing and professional skills. Out of 366 surveyed nurses, 65% who participated in clinical supervision said they felt well-trained, supported by their workplaces, and saw improvements in their relationship skills. This is important because it shows that effective training and support can enhance nurses’ practice, leading to better care for patients. Who this helps: This helps nurses and ultimately the patients they care for.

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This paper examines how COVID-19 was managed in Northern Ireland's prison system during the pandemic. Researchers found that strict measures, like screening new inmates, isolating those who might be infected, and halting non-essential activities, kept COVID-19 largely out of the prisons. Overall, the prison experience had significantly fewer COVID-19 cases compared to the general population, with no major infection spikes similar to those in the outside community. Who this helps: This helps prison staff, inmates, and public health officials planning for future health crises.

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This study looked at patients in the southeastern U.S. who were preparing for foot and ankle surgery to see how their living conditions affected their health. Out of 372 patients, those from neighborhoods with higher levels of social deprivation reported more pain and poorer physical function, with about a 17-point difference in the Foot Functional Index score between the least and most deprived groups. This is important because it shows that where someone lives can impact their experience of pain and physical health before surgery, potentially affecting their outcomes. Who this helps: This helps patients and healthcare providers understand the influence of social factors on surgical recovery.

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This study looked at a drug called Monensin and 37 similar compounds to see how well they work against breast cancer stem cells. The researchers found that some of these compounds were better at killing cancer cells than normal cells, and one compound notably decreased the number of stem-like cancer cells by a significant amount, which could stop the cancer from spreading. This discovery is important because it could lead to new treatments that specifically target aggressive breast cancer cells without harming healthy cells. Who this helps: This benefits breast cancer patients and their doctors by providing new treatment options.

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This paper addresses a mistake in a previous study about how light behaves when it encounters instability in heated fluids, a phenomenon known as Rayleigh-Bénard convection. The authors clarify the meaning of a specific constant that was incorrectly interpreted, which could affect the understanding of light patterns observed in these conditions. This matters because accurate interpretations of these patterns can improve applications in fields like meteorology and optical communications. Who this helps: This helps researchers and engineers working with optical systems in turbulent environments.

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This study examined urine samples from 174 patients, both with and without acute kidney injury (AKI), to understand why some people experience a decline in kidney function after being hospitalized. Researchers identified 387 proteins linked to faster decline in kidney function, with 71% of these proteins coming from kidney cells affected by AKI. This is important because it helps pinpoint specific biological markers that could predict kidney problems in patients who were recently hospitalized, which may lead to better care and intervention strategies. Who this helps: This helps patients at risk of kidney damage after hospitalization and their healthcare providers.

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This research studied Chinese hamster ovary (CHO) cells, which are important in making biopharmaceuticals. The scientists used a sophisticated method to delete large parts of the genome and found 427 regions necessary for the survival of these cells, many of which were previously unexplored and lack known functions. Understanding these essential genomic regions is crucial because it can lead to better-designed cells for producing medical treatments. Who this helps: This helps researchers and companies developing biopharmaceuticals.

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This study looked at the health challenges faced by critically ill children being treated in a Pediatric Intensive Care Unit (PICU) in Kigali, Rwanda. It found that 55% of the children admitted to the PICU died, with sepsis and respiratory failure being the most common causes. Delays in getting to the PICU were linked to higher death rates, especially in newborns who needed surgery, highlighting the need for quicker treatment. Who this helps: This research benefits patients and healthcare providers focusing on critically ill children in low-resource settings.

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This study looked at whether treatments of intravenous iron or erythropoietin (EPO) could improve hemoglobin mass, help people perform better in exercise, and reduce symptoms of acute mountain sickness (AMS) when spending 14 days at high altitude (3,094 meters). The researchers found that while hemoglobin mass increased overall, exercise performance did not improve for any group, and AMS symptoms were not significantly affected. This is important because it shows that neither iron nor EPO treatments provide benefits for people quickly going to high altitudes, even though they have been used in the past for similar purposes. Who this helps: This helps patients preparing for high-altitude activities and their healthcare providers.

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This study looked at how the expansion of Medicaid under the Affordable Care Act (ACA) affected enrollment for people experiencing homelessness in New Jersey and Pennsylvania. Researchers found that after the ACA expansion, enrollment rates increased by 7.5% in New Jersey and 8.5% in Pennsylvania. Additionally, individuals who used homeless services had even higher chances of enrolling—up to 18.6% more likely if they stayed in shelters for more than one month. Who this helps: This benefits individuals experiencing homelessness and the organizations that support them.

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This study looked at how infants with anorectal malformations (ARMs) were treated at a hospital in Rwanda from 2015 to 2023. Of the 62 babies studied, 17.9% died within 30 days after surgery, which is better than many other low and middle-income countries but still higher than in wealthier countries. The research found that babies who weighed less than 3,000 grams at the time of surgery were much more likely (94% higher odds) to die after the procedure, highlighting the need for careful monitoring of these infants' weight. Who this helps: This helps healthcare workers and surgeons who treat infants with ARMs, improving care and outcomes for these patients.

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This study looked at severe low sodium levels (hyponatremia) and other health issues after people participated in a Kambô ritual, where they apply toxins from a frog to their skin. The researchers found that the problems might be caused either by drinking too much water during the ritual or by a specific condition that disrupts sodium balance called SIADH. Understanding this helps doctors treat the symptoms effectively, leading to a quicker recovery for patients. Who this helps: Patients who experience health issues after Kambô rituals.

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This study looked at whether giving pharmacists the ability to prescribe COVID-19 vaccines affects vaccination rates in areas near state borders where some states allow pharmacists to prescribe and others do not. It found that in states where pharmacists could prescribe, there was a 5% increase in the number of adults who completed their initial COVID-19 vaccine series. This is important because it suggests that empowering pharmacists to prescribe can help increase vaccination rates and reduce hesitancy during health crises. Who this helps: This helps patients by making it easier for them to get vaccinated.

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This study looked at how a protein called focal adhesion kinase (FAK) affects the stability of another protein, PD-L1, in triple-negative breast cancer (TNBC), which is hard to treat. Researchers found that blocking FAK reduced PD-L1 levels in some lab cells, but surprisingly, it increased PD-L1 levels in TNBC cells. This is important because higher PD-L1 can help cancer cells evade the immune system, so targeting both FAK and PD-L1 might lead to better treatments for TNBC patients. Who this helps: Patients with triple-negative breast cancer.

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This study looked at how people learn and maintain conspiracy beliefs. Researchers found that when participants learned about a politician who might have been poisoned, they were less likely to notice new locations linked to illness if those locations were presented alongside a location tied to the conspiracy. Specifically, this means that the presence of the conspiracy made it harder for participants to learn about other important information, leading them to accept the conspiracy theory instead. Who this helps: This research helps psychologists and educators understand how conspiracy beliefs form, which can inform strategies to counter misinformation.

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This study looked at the survival rates of newborns with a condition called esophageal atresia, which affects the esophagus, at a hospital in Rwanda. Out of 56 babies treated, about 52% died within 30 days of surgery, but the care from specialized surgeons helped lower mortality rates compared to other similar hospitals in low- and middle-income countries. The research found that babies with other birth defects, especially heart problems, had a higher chance of dying. Who this helps: This is important for doctors and healthcare providers working with newborns who have complex congenital conditions.

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This research studied the effects of Monensin and 37 similar synthetic compounds on breast cancer cells in both flat and 3D models. The most effective compound significantly decreased the number of breast cancer stem-like cells, reduced their ability to migrate, and caused notable DNA damage. This is important because it shows promise for developing new treatments that can more effectively target aggressive breast cancer cells and prevent their spread. Who this helps: This helps patients with breast cancer by providing potential new treatment options.

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This study looked at night shift workers in Australia and the UK to see how common irritable bowel syndrome (IBS) and functional dyspepsia (FD) are among them. It found that 21.3% of these workers had IBS, 30.4% had FD, and 24.5% had both conditions, which is much higher than rates typically seen in the general population. The night shifts significantly impacted their quality of life and mental health, leading many to consider changing jobs due to their symptoms, indicating that these workers need better support for their gastrointestinal and mental health. Who this helps: This research benefits night shift workers who face gastrointestinal issues due to their job.

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This study looked at how well a new system on ships can measure primary production—essentially how much organic matter plants and algae produce—in the northern Gulf of Alaska, an area affected by freshwater from land. Researchers found that their model worked well in this complex marine environment and detected detailed patterns in productivity that traditional sampling methods missed. These findings are important because they improve our understanding of marine ecosystems and how they can be monitored more effectively. Who this helps: This benefits oceanographers and researchers studying marine environments.

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The research focused on how free-roaming dogs affect lemurs in Madagascar, a group of animals that are at high risk of extinction. Over ten years, it was found that these dogs not only hunt lemurs and other wildlife but also push them out of their habitats. The study noted that the presence of dogs in forests decreases wildlife populations and can spread harmful diseases to lemurs. Who this helps: This benefits conservationists and wildlife protectors working to save endangered species like lemurs.

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This study looked at how resilience affects recovery outcomes in patients who underwent surgery for issues like plantar fasciitis or Achilles tendinopathy. They found that higher resilience is linked with better physical function, less pain interference, and lower levels of depression after surgery. Specifically, a significant correlation was seen with improved scores across various measures: for example, resilience was associated with a 46% increase in physical function and a 53% decrease in disability levels. Who this helps: This benefits patients undergoing foot surgery by highlighting the importance of mental resilience in their recovery process.

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This study looked at how patients with Chronic Ankle Instability feel mentally, physically, and in terms of pain before and after Brostrom-Gould (BG) surgery. Out of 40 patients, those who had surgery reported a significant increase in their physical function and a decrease in pain, with improvements starting as early as 6 weeks after surgery. The results help set realistic expectations for patients about their recovery and overall wellbeing after surgery. Who this helps: Patients recovering from ankle surgery.

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This study looked at whether race affects how long patients stay in the hospital after elective foot and ankle surgeries. It found that black patients stayed in the hospital for about 3.35 days on average, while white patients stayed for about 3.08 days. Importantly, there were no differences in complication rates between these groups, which highlights longer hospital stays as a key area needing further investigation. Who this helps: This research benefits patients and healthcare providers by focusing on disparities in hospital care.

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This study looked at how resiliency—our ability to bounce back from stress—affects mental health after a specific surgery for Achilles problems. Researchers measured resilience and mental health before and after the surgery. They found that while mental health scores improved significantly from 49.22 to 50.11 two weeks after surgery, resilience didn't change much, remaining around 3.65. This matters because understanding the link between resilience and mental health can help healthcare providers support patients more effectively during recovery. Who this helps: This helps patients recovering from tendon surgery.

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This study examines a special diabetes education program called HEAL-D, designed specifically for Black African and Caribbean adults with type 2 diabetes. It compares the effectiveness of this culturally tailored program against standard diabetes education over a period of 24 months, with key health indicators likely assessed at 12 months. Initial findings suggest that adapting educational support to cultural needs could significantly enhance diabetes management outcomes in these communities, which face higher health disparities. Who this helps: This benefits Black African and Caribbean adults living with type 2 diabetes.

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This study looked at a modified surgical technique called the single-incision Broström-Gould surgery for fixing chronic ankle instability. The researchers found that this method allows surgeons to also perform a calcaneal osteotomy—a cut in the heel bone—without making additional cuts, which can lead to fewer complications. The new technique helps stabilize the ankle better, reduces pain, and may prevent future injuries, making it a promising option for patients looking for an effective treatment. Who this helps: This benefits patients with chronic ankle instability who have not had success with non-surgical treatments.

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This study looked at a new way to rebuild the top part of the shin bone (proximal tibia) after removing bone tumors in children. Researchers followed five patients who received a special device called a Compress® tibia hemiarthroplasty, which helped them avoid problems like differences in leg length. The patients, who were around 10 years old, had good movement in their knees, didn’t experience significant complications, and reported a high quality of life, with scores averaging 90 out of 100. Who this helps: This benefits pediatric patients with bone tumors and their doctors by providing a safer reconstruction option that preserves growth potential.