Dr. Jennings studies several health-related issues, including surgical techniques for repairing ear defects, the effectiveness of compression therapy after dermatologic surgery, and the dynamics of respiratory viruses like COVID-19 and RSV. He investigates how factors such as helmet fit can influence the risk of head injuries in athletes and works on methods to improve the understanding of tumor-related seizures in patients with specific brain tumors. His cross-disciplinary research aims to enhance patient care and safety through improved surgical practices and better understanding of public health trends.
Key findings
In a study on ear defect repairs, 90% of 15 patients rated their scars as desirable after treatment, indicating good cosmetic outcomes.
Research on helmet fit showed that improper padding can increase the risk of head injury by up to 20% during blunt impacts.
In a study of 35 patients with pleomorphic xanthoastrocytoma, 77% experienced tumor-related epilepsy, with 88% surviving five years post-treatment.
During the COVID-19 pandemic, 77 out of every 100 people experienced COVID-19, significantly higher than the 17 cases of influenza per 100 people.
Findings from wastewater analysis in Zambia revealed that 90% of 20 samples tested positive for human adenovirus, demonstrating the importance of monitoring public health risks.
Frequently asked questions
Does Dr. Jennings study head injuries?
Yes, Dr. Jennings researched how the fit of helmets affects head injury risk, finding improper fit can increase injury likelihood.
What treatments has Dr. Jennings researched?
He has researched surgical techniques for ear defects, the impact of compression therapy after surgery, and methods to manage seizures related to brain tumors.
Is Dr. Jennings's work relevant to patients recovering from surgery?
Yes, his research includes studies on optimizing surgical outcomes and recovery processes, particularly in dermatologic and reconstructive surgeries.
What does Dr. Jennings study about respiratory illnesses?
He studies the transmission dynamics of respiratory viruses like COVID-19 and RSV, providing insights that help manage these infections in the community.
Can Dr. Jennings's research help improve public health measures?
Absolutely, his work on illness transmission and environmental monitoring supports public health initiatives to prevent outbreaks and improve community health.
Publications in plain English
Early Takedown of Postauricular, Melolabial, and Paramedian Forehead Interpolation Flaps: A Retrospective Cohort Study.
2026
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Scherz LA, Renzi M, Jennings T, Lawrence N
Plain English This study looked at the safety of removing skin flaps used in facial reconstruction surgery sooner than usual—within 2 weeks instead of the typical 3 weeks—across three types of surgical flaps. Researchers found that doing this earlier did not lead to more complications, such as infections or wound issues, in 141 patients, showing similar results for people whose flaps were removed early compared to those who had them removed later. This matters because it suggests patients might experience less discomfort and a better quality of life without an increased risk after surgery.
Who this helps: Patients undergoing facial reconstruction surgery.
Population Variations in Helmet Fit Affect Calculated Head Injury Risk in Blunt Impact.
2026
Journal of biomechanical engineering
Jennings T, Amini R, Müftü S
Plain English This study examined how the fit of helmets can influence the risk of head injuries during blunt impacts. Researchers found that when the padding in a helmet compressed more, the force on the head increased, resulting in up to a 20% higher risk of injury to the brain and skull. This matters because it shows that ensuring a proper fit could be crucial for reducing injury risk, especially in sports like American football, where athletes experience frequent, low-level impacts.
Who this helps: This helps athletes, especially in contact sports, and helmet manufacturers.
Longitudinal risk of cutaneous squamous cell carcinoma development following PD-1 inhibitor therapy for melanoma: A retrospective TriNetX cohort study.
An Integrated Multiphoton Imaging Workflow for Quantitative Analysis of Aortic Tissue Microstructure.
2026
bioRxiv : the preprint server for biology
Baig MMJ, Vargas AI, Jennings T, Amini R, Bellini C
Plain English This research focused on developing a new method for analyzing the structure of the aorta, the main blood vessel in the body, using advanced imaging techniques. The study found that by measuring the thickness of elastic layers, spacing between them, and the properties of cells and fibers, they could create a reliable way to assess changes in the aorta's structure. This is important because understanding these changes can help scientists explore how the aorta functions in both healthy and diseased states.
Who this helps: This benefits researchers and healthcare professionals studying cardiovascular health.
Sculpo Repair: Linear Closure With Cartilage Sculpting for Helical Rim Defects ≤ 2.5 cm².
2026
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Scherz LA, Rivard S, Kim Y, Renzi MA, Jennings T +1 more
Plain English This study looked at a method called linear closure with cartilage sculpting to repair ear defects that are 2.5 cm² or smaller. The researchers treated 15 patients and found minimal complications, with 6.7% experiencing a minor issue. Most patients had scar ratings indicating good cosmetic outcomes, with 90% describing the appearance of their scars as desirable.
Who this helps: This benefits patients who have had surgeries for helical rim defects on the ear.
Toward a Consistent Framework for Describing the Free Vibration Modes of the Brain.
2025
Journal of biomechanical engineering
Jennings T, Amini R, Müftü S
Plain English This study looked at how the brain moves in response to vibrations, like those caused by impacts or the environment. The researchers created a detailed model of the head and identified specific natural frequencies and vibration patterns of the brain. They found that many of the patterns they observed matched those seen in previous studies, which helps standardize how brain vibrations are described and compared in future research.
Who this helps: This benefits researchers and doctors studying brain injuries and their effects.
Measurement and Assessment of Head-to-Helmet Contact Forces.
2025
Annals of biomedical engineering
Jennings T, Tillman A, Mukasa D, Marchev M, Müftü S +1 more
Plain English The study looked at how different people's heads interact with their helmets by measuring the forces exerted when wearing them. Researchers found that most pressure on the interior pads of helmets was low, between 0 and 5 newtons, but some areas could see pressures as high as 30 newtons, especially at the front of the helmet. This research reveals that head shape and helmet fit can vary significantly between individuals, especially between men and women, highlighting that existing helmet sizing methods may not be sufficient to ensure a proper fit.
Who this helps: This helps patients, particularly athletes and individuals who wear helmets for safety, by promoting better helmet fitting.
Comparison of the Incidence and Risk Factors of Acute Respiratory Illness Associated With COVID-19 and Influenza: Results of the SHIVERS II, III, and IV Prospective Community Cohort Study.
2025
The Journal of infectious diseases
Huang QS, Wood T, Aminisani N, Kvalsvig A, Baker MG +20 more
Plain English This study looked at the rates of respiratory illnesses caused by COVID-19 and influenza in the Wellington community from February to October 2022. The findings showed that COVID-19 cases were significantly more common, with a rate of 77 out of every 100 people over one year, compared to just 17 for influenza. The research also found that while children make up a larger percentage of influenza cases, adolescents aged 12 to 17 had the highest rates of COVID-19, and those vaccinated against COVID-19 were more likely to get infected than fully vaccinated adults.
Who this helps: This research benefits public health officials and healthcare providers who need to understand the spread and impact of respiratory illnesses in the community.
Assessing the Efficacy of Compression Therapy on Second Intention Wound Healing After Dermatologic Surgery: A Randomized, Controlled Trial.
2025
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Scherz LA, Walkosak CC, Renzi MA, Jennings T, Tvedten E +1 more
Plain English This study looked at whether wearing compression stockings helps wounds heal faster after dermatologic surgery on the lower legs. It involved 40 patients who were either given standard wound care or compression therapy. The results showed that both groups had similar healing times, with the compression group taking an average of 9.48 weeks to heal compared to 10 weeks for standard care, meaning compression therapy did not significantly speed up healing.
Who this helps: This information benefits patients recovering from dermatologic surgery on their legs.
Seizure characteristics and outcomes in patients with pleomorphic xanthoastrocytoma.
2025
Neuro-oncology advances
Zhou DJ, Ellis CA, Xie K, Sinha N, Xie SX +8 more
Plain English This study looked at patients with pleomorphic xanthoastrocytomas (PXAs), rare brain tumors often linked to seizures. Out of 35 patients, 77% developed tumor-related epilepsy, with 71% experiencing seizures before their diagnosis. Those who became seizure-free after surgery were generally younger at the time of their first seizure and had smaller tumors, but overall survival rates were similar whether or not they had seizures, with 88% alive five years after treatment.
Who this helps: This research benefits patients with PXAs and their doctors by providing insights into managing seizures related to these tumors.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Tvedten E, Jennings T, Alam M, Carr D, Carucci J +3 more
Plain English This paper looks at how dermatologic oncology, the study of skin cancers, has progressed over the last 50 years, focusing primarily on the most common skin cancers like melanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC), while also mentioning rarer types such as Merkel cell carcinoma (MCC). The research highlights that since 1975, there have been over 2,258 studies on melanoma alone, with dermatologic surgery publishing 602 of those, indicating a strong contribution to the field. This increased understanding and research matter because they help improve diagnosis and treatment options for skin cancer patients.
Who this helps: Patients and doctors involved in skin cancer treatment and research.
Procedural and surgical treatment modalities for acne scarring: Part II.
2024
Journal of the American Academy of Dermatology
Renzi M, McLarney M, Jennings T, Duffy R, Heymann WR +2 more
Plain English This paper examines various effective treatments for acne scarring, including chemical peels, fillers, radiofrequency microneedling, lasers, and surgical options. It looks at how well these treatments work, their benefits, and potential side effects to help doctors choose the best option for their patients based on their unique scars and skin types. Understanding these treatments is important because it can significantly improve the quality of life for those affected by acne scars.
Who this helps: This helps patients looking for effective options to treat their acne scars.
Acne scarring-pathophysiology, diagnosis, prevention and education: Part I.
2024
Journal of the American Academy of Dermatology
Jennings T, Duffy R, McLarney M, Renzi M, Heymann WR +2 more
Plain English This research paper looks at acne scarring, which is a common problem that can lead to serious emotional distress for affected individuals, including issues like depression. It highlights that even when acne is treated well, scars can still form and may be neglected during treatment. The study emphasizes the importance of assessing different types of acne scars to provide better, personalized treatment, ultimately improving patient outcomes.
Who this helps: Patients with acne scars and their healthcare providers.
Bacterial Organisms Colonizing Mohs Surgical Wounds Healing by Second Intention on the Lower Extremities: A Prospective, Controlled Study.
2024
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Renzi MA, Jennings T, Lawrence N, Decker A
Plain English This study looked at bacterial infections in surgical wounds on the lower leg that are healing without stitches, known as "second intention" wounds, after a specific type of skin cancer surgery. Researchers found that the bacteria Staphylococcus aureus was present in both infected (15.7%) and non-infected wounds (9.8%), with 32% of the infected wounds hosting only normal skin bacteria, indicating the difficulty in diagnosing true infections. This matters because it highlights how challenging it can be for doctors to identify infections correctly, which can lead to unnecessary antibiotic use.
Who this helps: This helps patients and doctors manage wound care more effectively.
Vascular Remodeling During Late-Gestation Pregnancy: An In-Vitro Assessment of the Murine Ascending Thoracic Aorta.
2024
Journal of biomechanical engineering
Vargas AI, Tarraf SA, Jennings T, Bellini C, Amini R
Plain English This study looked at changes in blood vessels in pregnant mice to understand how pregnancy affects cardiovascular health. Researchers found that during late pregnancy, the aorta, a major blood vessel, expanded in size, with about a 12% increase in wall thickness and a 6% increase in diameter, while still maintaining its ability to function properly despite increased blood flow. These findings are important because they help explain how pregnancy might affect women's heart health in the long term.
Who this helps: This helps pregnant women and healthcare providers understand the cardiovascular changes that can occur during pregnancy.
Impact of the COVID-19 related border restrictions on influenza and other common respiratory viral infections in New Zealand.
2024
Influenza and other respiratory viruses
Huang QS, Turner N, Wood T, Anglemyer A, McIntyre P +53 more
Plain English This study examined how New Zealand's COVID-19 border restrictions affected the spread of influenza and other common respiratory viruses. Researchers found that after May 2020, the country had no community cases of influenza or RSV, largely due to these restrictions; however, when some travel measures were lifted, RSV returned in 2021, and influenza appeared in 2022. These findings highlight the importance of border controls in managing respiratory virus outbreaks during pandemics.
Who this helps: This benefits public health officials and policymakers in managing future viral infections.
An Experiential Learning Opportunity in Norway: Computation for Bioengineering and Mechanical Engineering Students.
2024
Journal of biomechanical engineering
Clarin J, Vargas AI, Jennings T, Salinas SD, Amini R +10 more
Plain English This study looked at a program in Norway that teaches mechanical and bioengineering students important computing skills while also helping them think critically about technology's cultural and social effects. It found that after participating, students reported greater self-confidence, with female students feeling more confident about their future success compared to male students. This matters because it shows the value of combining technical education with real-world experiences, especially in understanding social issues and cultural contexts.
Who this helps: This benefits engineering students, particularly those seeking to improve their intercultural communication and confidence in their careers.
Water-Soluble Fluorescent Polymer Dyes with Tunable Emission Spectra for Flow Cytometry Applications.
2024
Angewandte Chemie (International ed. in English)
Berndt D, Glaap D, Jennings T, Dose C, Werz DB +1 more
Plain English Researchers created new bright, water-soluble dyes that fluoresce in different colors when used with a specific type of laser. These dyes can be used in flow cytometry, a method that helps identify and sort different types of cells in a sample. The study found that these new dyes can work together with existing dyes, making it possible to analyze more cell types at once. This is significant because it enhances the ability to study complex biological systems, which is crucial for various medical applications.
Who this helps: This helps patients and researchers who study diseases by improving cell analysis techniques.
Justifying the need for a recovery related surveillance system: Exploratory focused interviews.
2024
Health science reports
Ellis J, Clancy GL, Kizewski A, Jennings T, Thompson RA +2 more
Plain English This study looked at how recovery houses collect information about their residents and found significant gaps in this process. Out of 16 representatives interviewed, 92% collected data when residents entered, but only 31% collected information after residents left. This is important because a standardized system for tracking recovery progress could enhance the care offered to individuals and help improve long-term outcomes for those recovering from substance use issues.
Who this helps: This helps patients in recovery by ensuring they receive better support and care.
Detection of Human Adenovirus and Rotavirus in Wastewater in Lusaka, Zambia: Demonstrating the Utility of Environmental Surveillance for the Community.
2024
Pathogens (Basel, Switzerland)
Saasa N, M'kandawire E, Ndebe J, Mwenda M, Chimpukutu F +34 more
Plain English This study looked at wastewater in Lusaka, Zambia, to find two common viruses—human adenovirus and rotavirus—that can cause serious stomach illnesses. Out of 20 wastewater samples, 90% showed the presence of human adenovirus, and 70% had rotavirus. This finding highlights the need for regular monitoring of wastewater to better understand public health risks in the community.
Who this helps: This research benefits public health officials and community health organizations working to prevent viral infections.
Spatial and temporal transmission dynamics of respiratory syncytial virus in New Zealand before and after the COVID-19 pandemic.
2024
medRxiv : the preprint server for health sciences
Jelley L, Douglas J, O'Neill M, Berquist K, Claasen A +23 more
Plain English This study looked at how the respiratory syncytial virus (RSV) spread in New Zealand before and after COVID-19 measures were put in place. Researchers found that in 2021, RSV cases jumped to more than five times higher than normal, leading to over three times the usual hospitalizations, particularly after travel restrictions were lifted. This matters because it shows how controlling one virus can affect the spread of another and provides valuable information from the genetic makeup of the virus.
Who this helps: This research benefits public health officials and healthcare providers by informing them about RSV transmission and patterns.
Spatial and temporal transmission dynamics of respiratory syncytial virus in New Zealand before and after the COVID-19 pandemic.
2024
Nature communications
Jelley L, Douglas J, O'Neill M, Berquist K, Claasen A +24 more
Plain English Researchers studied how the respiratory syncytial virus (RSV) spread in New Zealand before and after COVID-19 pandemic measures. They found that in 2021, RSV cases surged to more than five times the usual levels after restrictions were lifted and travel resumed, with significant genetic changes in the virus. This is important because it shows how the steps taken to control COVID-19 affected other respiratory viruses and helps us understand their behavior better.
Who this helps: This research benefits public health officials and healthcare professionals by providing insights into the management of viral infections.
Tracing household transmission of SARS-CoV-2 in New Zealand using genomics.
2024
Npj viruses
Jelley L, Aminisani N, O'Neill M, Jennings T, Douglas J +12 more
Plain English This study looked at how the Omicron variant of COVID-19 spread within 71 households in New Zealand. Researchers found that about 80% of these households experienced infections with the BA.2 variant, and 92% had one main source of infection spreading through the household. The results confirm that households are high-risk environments for COVID-19 transmission, supporting the need for isolation rules for infected individuals and their close contacts.
Who this helps: This helps patients and public health officials in managing COVID-19 risks in household settings.
"Sex Seems Less Important When You Are Worried About a Deadly Virus." A Content Analysis of Reported Reasons for Changes in Sexual Behavior and Satisfaction During the COVID-19 Pandemic.
2023
Journal of sex & marital therapy
Gleason N, Conroy K, Taylor S, Smith L, Gasser M +4 more
Plain English This study looked at how the COVID-19 pandemic affected people’s sexual behaviors and their satisfaction in relationships by analyzing responses from over 1,000 American adults. Many participants reported feeling more worried and stressed, which led to either changes in their sexual activity or a decrease in satisfaction with their relationships. Understanding these impacts is important for addressing the emotional and relational needs of people during and after such crises.
Who this helps: This helps patients and mental health professionals understand the relationship between stress and sexual health during pandemics.
The Relationship between Boredom Proneness, Attachment Styles and Compulsive Sexual Behavior.
2023
Journal of sex & marital therapy
Coleman E, Rahm-Knigge RL, Danielson S, Nielsen KH, Gleason N +2 more
Plain English This study looked at how feeling bored and different types of emotional connections (or attachment styles) affect people who engage in compulsive sexual behavior (CSB). Researchers found that people who are more prone to boredom tend to show more CSB, especially if they also have high attachment anxiety. This research is important because it highlights how understanding these emotional factors can help in treating individuals with compulsive sexual behavior.
Who this helps: This helps patients struggling with compulsive sexual behavior and the professionals treating them.
Systematic review and meta-analysis comparing perioperative outcomes of emergency appendectomy performed by trainee vs trained surgeon.
2023
American journal of surgery
Anyomih TT, Jennings T, Mehta A, O'Neill JR, Panagiotopoulou I +5 more
Plain English This study examined the results of appendectomies (removal of the appendix) done by trainee surgeons compared to experienced surgeons. Out of over 135,000 surgeries reviewed, the researchers found no differences in serious outcomes like death or major complications, although trainee surgeries took about 8 more minutes on average. However, surgeries by trainees led to shorter hospital stays and a lower chance of needing a second surgery.
Who this helps: This benefits patients undergoing appendectomy, reassuring them that trainee surgeons can perform the procedure safely.
The Relationship between Compulsive Sexual Behavior, Religiosity, and Moral Disapproval.
2023
Journal of sex & marital therapy
Coleman E, Jennings T, Gleason N, Danielson S, Nielsen KH +2 more
Plain English This study looked at how people's religious beliefs and feelings about sexual behavior relate to compulsive sexual behavior (CSB). Researchers found that those with strong and rigid religious beliefs experienced higher levels of CSB; specifically, higher moral disapproval of sexual behavior was linked to these tendencies. Understanding these connections is important because it helps explain why some individuals may struggle with sexual behaviors that conflict with their values.
Who this helps: This helps patients dealing with compulsive sexual behavior and mental health professionals supporting them.
Confirming and Expanding the Moral Incongruence Model of Compulsive Sexual Behavior.
2023
Archives of sexual behavior
Gleason N, Jennings T, Rahm-Knigge RL, Nielsen KH, Danielson S +2 more
Plain English This study looked at how people feel about their sex-related behaviors compared to their moral beliefs. Researchers surveyed 804 Americans and found that those who frequently used pornography were more likely to report problems with their sexual behaviors, especially if they had strong moral disapproval of those behaviors. The study also found that while some connections exist between sexual fantasies and sexual partners with moral beliefs, masturbation didn’t show the same pattern.
Who this helps: This helps mental health professionals and researchers understand the complexities of compulsive sexual behaviors and how moral beliefs affect them.
What's gut got to do with it? The role of the microbiota and inflammation in the development of adiposity and obesity.
2023
Immunometabolism (Cobham, Surrey)
Jennings T, Janquart M, Washak C, Duddleston K, Kurtz C
Plain English This study looked at how gut bacteria and inflammation contribute to obesity, which is when the body has too much fat. Researchers found that when gut bacteria become imbalanced, it can damage the gut barrier, allowing harmful substances to enter the bloodstream and cause inflammation. This inflammation worsens fat accumulation and leads to health problems associated with obesity.
Who this helps: This helps patients struggling with obesity and the doctors treating them.
Lithic usewear confirms the function of Wilamaya Patjxa projectile points.
2023
Scientific reports
Smallwood A, Haas R, Jennings T
Plain English Researchers studied ancient projectile points found in graves at the Wilamaya Patjxa site in the Andes, dating back about 9,000 years. They discovered that both men and women in that community likely hunted large mammals, as the points showed signs of being used for that purpose, along with evidence of processing animals. This finding indicates that hunting was a shared activity between genders in these early foraging societies, suggesting more equal roles in survival activities.
Who this helps: This benefits historians and archaeologists studying gender roles in ancient cultures.
Cr and CeOpromoted Ni/SBA-15 framework for hydrogen production by steam reforming of glycerol.
2023
Environmental science and pollution research international
Abrokwah RY, Ntow EB, Jennings T, Stevens-Boyd R, Hossain T +5 more
Plain English This study focused on improving a catalyst made from nickel and silica for producing hydrogen from glycerol, a byproduct of biodiesel. The researchers found that the best-performing catalyst, 12Ni-SBA-15, achieved 99.9% glycerol conversion, while variations with chromium and cerium improved long-term stability, maintaining around 58% hydrogen selectivity and near 100% conversion for 60 hours. This research is important because generating hydrogen from renewable sources like glycerol can be a cleaner energy alternative and help lower carbon emissions.
Who this helps: This benefits researchers and companies working on sustainable energy solutions.
Long-term psychological outcomes following stroke: the OX-CHRONIC study.
2023
BMC neurology
Kusec A, Milosevich E, Williams OA, Chiu EG, Watson P +11 more
Plain English This study focused on the long-term psychological effects experienced by stroke survivors more than two years after their stroke. It found that 65.3% of participants had cognitive problems, 51.4% experienced fatigue, and significant rates of depression and anxiety were reported (23.5% for depression and 22.5% for anxiety). These psychological issues affect the quality of life for stroke survivors, highlighting the need for ongoing support and treatment strategies.
Who this helps: This research benefits stroke survivors and healthcare providers working with them.
Examining the interdisciplinary approach for treatment of persistent post-concussion symptoms in adults: a systematic review.
2023
Brain impairment : a multidisciplinary journal of the Australian Society for the Study of Brain Impairment
Jennings T, Islam MS
Plain English This review examined how combining different types of medical care helps adults with long-lasting symptoms after a concussion. The studies showed that using an interdisciplinary approach, which involves multiple healthcare professionals, can significantly reduce these symptoms, but the results varied across different cases. Knowing that this method works can improve treatment plans and support for patients recovering from concussions.
Who this helps: This helps patients suffering from lasting concussion symptoms and the healthcare providers treating them.
Assessing Technical Assistance Needs among Recovery Residence Operators in the United States.
2022
Journal of psychoactive drugs
Miles J, Bunn T, Kizewski A, Jennings T, Waters T +3 more
Plain English This study looked at what kind of support recovery housing operators in the U.S. need to improve their services for people recovering from addiction. Out of 376 individuals surveyed, 77 responded, revealing that those who run a single recovery house want help with specific policies and connecting to care services, while those with multiple houses are focused on making their operations financially sustainable and using proven best practices. These findings highlight that as more states aim to certify recovery residences, providing tailored training will help these operators meet quality standards and better support their residents.
Who this helps: This benefits recovery housing operators and the individuals they serve.
A systematic review of the literature assessing operative blood loss and postoperative outcomes after colorectal surgery.
2022
International journal of colorectal disease
Charalambides M, Mavrou A, Jennings T, Powar MP, Wheeler J +3 more
Plain English This study looked at how blood loss during colorectal surgery affects patients' recovery and long-term health. It found that significant blood loss is linked to higher risks of complications like infection and longer hospital stays, as well as increased chances of future issues like bowel obstruction and cancer recurrence. Reducing blood loss during surgery could lead to better outcomes for patients.
Who this helps: This helps patients undergoing colorectal surgery, as well as their doctors in improving surgical practices.
Extracting seizure frequency from epilepsy clinic notes: a machine reading approach to natural language processing.
2022
Journal of the American Medical Informatics Association : JAMIA
Xie K, Gallagher RS, Conrad EC, Garrick CO, Baldassano SN +17 more
Plain English This study focused on developing a way to automatically find and extract information about epilepsy patients' seizure frequency and whether they are seizure-free from their medical notes. Researchers tested three advanced computer models and found that their best models could accurately identify patients as seizure-free over 80% of the time and successfully extract seizure frequency and the date of the last seizure with similar high accuracy. This work is important because it can help doctors make better decisions and allows for easier research on epilepsy by quickly analyzing large sets of clinical data.
Who this helps: This helps doctors and researchers working with epilepsy patients.
Recurrence Rate for Melanoma Excised by Mohs Micrographic Surgery Without Immunostaining.
2022
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Vieira C, Jennings T, Renzi MA, Lawrence N, Decker A
Plain English This study looked at how effective Mohs micrographic surgery (MMS) is for treating skin melanoma, focusing on the rates of cancer returning after treatment. Researchers found that overall, melanoma returned in just 2.6% of patients, with even lower rates for noninvasive melanoma at 1.6% compared to 7% for invasive melanoma. This is important because it shows that MMS can successfully treat melanoma while potentially allowing for smaller surgical margins, especially for noninvasive types.
Who this helps: Patients with melanoma, especially those with noninvasive forms of the disease.
Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.
2022
PloS one
Flory A, Kruglyak KM, Tynan JA, McLennan LM, Rafalko JM +60 more
Plain English Researchers studied a new blood test designed to detect multiple types of cancer in dogs. They found that the test correctly identified cancer in 54.7% of the dogs diagnosed with cancer, while also showing a very high accuracy rate of 98.5% for ruling out cancer in healthy dogs. Notably, the test performed particularly well for aggressive cancers, detecting them 85.4% of the time. This is important because it offers a noninvasive way to spot cancer early, which could help in treating dogs more effectively before symptoms appear.
Who this helps: Pet owners and veterinarians.
Plain English This research looks at a rare case of basal cell carcinoma, a type of skin cancer, that developed around an ear piercing in a 55-year-old woman. The study found that the cancer had spread from the piercing site to nearby areas of her ear, suggesting that the piercing may have helped the cancer spread. This is significant because it highlights the need to carefully examine any changes around piercings, especially if they cause ongoing irritation, to prevent further complications.
Who this helps: Patients with ear piercings and skin cancer concerns.
Acquired Lymphangiectasia in the Setting of a Gastrointestinal Stromal Tumor.
2022
Skinmed
Richards E, Jennings T, Heymann WR, Introcaso CE
Plain English This study looked at a 53-year-old woman who discovered unusual skin bumps while getting screened for skin cancer. Over three years, she noticed these bumps growing in number, but they didn't hurt or itch. Understanding these skin changes can help doctors better treat patients with similar symptoms linked to gastrointestinal tumors.
Who this helps: Patients with gastrointestinal tumors experiencing skin changes.
Systematic review and meta-analysis comparing perioperative outcomes of pediatric emergency appendicectomy performed by trainee vs trained surgeon.
2022
Pediatric surgery international
Anyomih TTK, Jennings T, Mehta A, O'Neill JR, Panagiotopoulou I +5 more
Plain English This study compared the outcomes of appendicitis surgeries in children performed by trainee surgeons versus experienced surgeons. It found there were no significant differences in complications, operation times, or need for reoperations between the two groups, with one notable exception: trainees were less likely to need to switch to a more invasive open surgery, doing so only 14% of the time compared to trained surgeons. This matters because it shows that surgical trainees can safely perform this common procedure without putting patient safety at risk.
Who this helps: Patients undergoing appendicitis surgery.
Evaluating a school-based science program that teaches the physiological effects of nicotine.
2021
Addictive behaviors
Cameron JL, Brasch K, Strong D, Paul B, Cavanaugh E +5 more
Plain English This study examined a school program that teaches students about the effects of nicotine using flatworms to demonstrate how nicotine affects behavior. The researchers found that after participating in a hands-on lab, 6th-12th grade students significantly improved their understanding of nicotine, with 6th graders starting with only about 41% correct knowledge and moving up to over 60% after the lab. The modifications allowed even younger 4th and 5th graders to also show significant improvements in their knowledge.
Who this helps: This helps students by providing them with important information about the dangers of nicotine.
Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand.
2021
Nature communications
Huang QS, Wood T, Jelley L, Jennings T, Jefferies S +46 more
Plain English The study looked at how lockdowns and border closures in New Zealand during the COVID-19 pandemic affected cases of influenza and other respiratory infections. Researchers found that in 2020, there was a significant drop in reported cases of these viruses, showing that these strict measures led to fewer infections. This is important because it shows that similar strategies can be effective in controlling not just COVID-19, but also influenza and other serious respiratory illnesses.
Who this helps: This benefits public health officials and healthcare providers.
Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents.
2021
The New England journal of medicine
Frenck RW, Klein NP, Kitchin N, Gurtman A, Absalon J +22 more
Plain English This research studied the BNT162b2 Covid-19 vaccine in adolescents aged 12 to 15. The findings showed that the vaccine produced a strong immune response, better than that in young adults aged 16 to 25, and had a 100% effectiveness in preventing Covid-19 in this age group among those who had not previously been infected. The vaccine was also safe, with mostly mild side effects like pain at the injection site and fatigue.
Who this helps: This benefits adolescents and their families by providing effective protection against Covid-19.
Kratom pharmacology: Clues from planarians exposed to mitragynine.
2021
Physiology & behavior
Uddin S, Wiah S, Kim T, Watson MN, Jennings T +1 more
Plain English This study investigated the effects of mitragynine (MG), a key compound in kratom, on planarians, which are a type of flatworm. Researchers found that while short-term exposure to MG had no impact on the worms' movements, those that had been exposed to MG over time showed reduced movement when they stopped using it. Additionally, MG caused changes in the worms' behavior that could be blocked by a drug called naltrexone, indicating that MG acts similarly to opioids across different species.
Who this helps: This research aids scientists and medical professionals in understanding how kratom affects the body and could have implications for treatment approaches regarding pain management.
An acute, ulcerative, sarcoidal tattoo reaction following SARS-CoV-2 mRNA-1273 vaccination.
2021
Dermatology online journal
Manci R, Jennings T, Mclarney RM, Heymann WR, Sommer LL
Plain English This study looked at a 38-year-old woman who developed painful ulcers on her tattoo after getting the Moderna COVID-19 vaccine. Two weeks after her first shot and worsening after her second, a biopsy showed that her body had a specific immune response, leading to what was diagnosed as a sarcoidal reaction. The ulcers improved after using a prescribed cream for two weeks.
Who this helps: This research helps patients who experience unusual skin reactions following vaccination and their healthcare providers.