THOMAS PRIESTLEY JANSSEN, MD

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This study looked at how positive self-identity affects the mental health and HIV prevention efforts of Black men who have sex with men. It found that out of 225 participants, those with a strong sense of cultural identity experienced better mental health, such as more social support and less depression. Specifically, those with a mix of positive identity feelings scored highest on PrEP adherence, suggesting that feeling good about one's identity can lead to better health practices. Who this helps: This benefits Black men who have sex with men by supporting their mental health and encouraging effective HIV prevention.

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This study looked at a treatment called MRI-guided stereotactic body radiation therapy (SBRT) for patients with liver metastases, involving 135 patients across several countries. The results showed that 97% of patients completed their treatment without any major issues, and only a small number experienced significant side effects, with just 1 patient reporting a serious radiation-related problem. However, many patients did report a decline in quality of life regarding issues like fatigue and pain three months after treatment. Who this helps: This benefits patients with liver metastases and their healthcare providers.

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The study looked at a new approach called online dose-adaptive radiotherapy (DART) for treating rectal cancer, which adjusts treatment plans based on the amount of radiation patients have already received. Researchers found that with DART, the amount of healthy tissue exposed to radiation decreased significantly: the dose in the area surrounding the tumor dropped by 3.6 Gy, and the volume of healthy tissue affected by radiation decreased by about 32%. This is important because it means that patients can receive effective treatment with less damage to healthy tissue. Who this helps: This helps cancer patients receiving radiation therapy.

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This study looked at a new way to treat intermediate-risk prostate cancer by adjusting radiation doses—higher doses to the tumor and lower doses to healthy tissue—using advanced MRI technology. Out of 60 patients, 54 were analyzed, and 46 of them (85%) received a sufficient dose to their tumors as planned. The findings suggest that while this approach can be effective in reducing side effects, it didn't consistently guarantee the best tumor coverage across all treatment centers. Who this helps: This helps patients with prostate cancer by exploring safer radiation options.

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This study examined whether the spaces around the prostate cancer treatment area, known as margins, are larger than necessary in adaptive radiotherapy. Researchers found that these margins can be reduced by about 2 millimeters, making the treatment more precise while still ensuring that the cancer cells are targeted effectively. This is important because reducing margins can lead to less radiation exposure to surrounding healthy tissue and improve treatment outcomes for patients. Who this helps: This helps prostate cancer patients by potentially improving the effectiveness of their treatment and reducing side effects.

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This study examined how well semi-supervised learning models for detecting aggressive prostate tumors in MRI scans performed compared to traditional fully supervised models that rely on expert input. Researchers analyzed 1,500 MRI scans and found that while the fully supervised model had the best performance with an accuracy score (AUC) of 0.89, the semi-supervised method achieved a similar performance of 0.86 on external validation datasets, showing it can be nearly as effective even when expert annotations are limited. This is important because it suggests that using semi-supervised techniques could speed up the development of AI tools for cancer detection, making them more widely available to help diagnose prostate cancer. Who this helps: Patients at risk of prostate cancer and healthcare providers looking for efficient diagnostic tools.

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This study looked at a new way to deliver radiotherapy for prostate cancer using MRI technology without needing to prepare a specific plan for each patient. Researchers tested this method on ten patients and found that it provided excellent coverage of the treatment area (over 99%) and worked nearly as well as traditional methods, but with some small increases in radiation to nearby organs. This approach saves time and resources, making treatment more efficient. Who this helps: This benefits prostate cancer patients by potentially speeding up their treatment process.

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This study looked at how well a drug called regorafenib works for patients with advanced melanoma who have already tried other treatments. Out of 16 patients, 37.5% had a significant reduction in their tumors, and 56% experienced some level of disease control. For a specific group of patients with a KIT mutation, 78% showed a positive response, with an average time before their cancer worsened of about 43 weeks. Who this helps: This research benefits patients with advanced melanoma, especially those with KIT mutations, by offering a potentially effective treatment option.

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This study looked at a new type of electronic device made from a material called TaIrTe, which operates at very high frequencies, from 19 MHz to 2.88 THz, and can convert different frequencies without needing external power or magnets. It found that this device works well and efficiently, with a passive mixer producing a conversion gain of -20 dB, making it suitable for advanced technologies like 6G. This advancement is important because it can help improve energy harvesting and signal processing for future electronic devices. Who this helps: This benefits engineers and researchers developing next-generation electronic technologies.

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Researchers studied how using infrared light to excite certain vibrations in a material called dysprosium orthoferrite affects its magnetic properties. They discovered that this can lead to a quick change from one magnetic state to another, with the change happening in two distinct phases: initially, the magnetization is uniform and influenced by the light's direction, and later it settles into a more complex pattern. This study is important because it reveals how we can control magnetic properties in materials much faster than previously thought, which could lead to advances in technology such as data storage and processing. Who this helps: This benefits scientists and engineers working on advanced materials and technology applications.

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This study looked for specific particles called light pseudoscalar bosons, which are believed to come from the decay of a Higgs boson during high-energy proton collisions. Researchers analyzed data collected from experiments at a particle collider and found no evidence of these particles, setting strict limits on how often they might occur, with a sensitivity down to one in a million (10^-5) for certain mass ranges. This research is important because it helps scientists understand the fundamental particles of the universe and enhances our ability to search for new physics. Who this helps: This helps physicists and researchers studying fundamental particle interactions and the nature of the universe.

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This study investigated a process called mixing-induced CP violation in a specific type of particle decay, known as B_{s}^{0}→J/ψϕ(1020). Researchers analyzed nearly 27,500 instances of this decay and found evidence of a measurable weak phase of -75±23 mrad, which indicates that the behavior of these particles is not entirely symmetrical, differing from zero with a significant difference of 3.2 standard deviations. This finding is important because it supports existing theories in particle physics and helps us understand fundamental symmetries in nature. Who this helps: This benefits physicists and researchers studying the laws of the universe.

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This study looked at what happens when oxygen nuclei collide at ultra-high speeds and how it relates to a state of matter called quark-gluon plasma. Researchers found that the production of certain particles is reduced in these collisions, with a significant suppression measured at a level of 0.69 when looking at particles with high energy. This is important because it helps us understand how particles lose energy in dense nuclear matter, contributing to our knowledge of fundamental physics and the conditions that existed shortly after the Big Bang. Who this helps: This helps physicists studying the early universe and the fundamental forces of nature.

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The study focused on creating a standardized way to document artificial intelligence (AI) models used in radiotherapy, which is important for both research and clinical settings. The team of 16 experts developed a structured template that includes key information such as model specifications, training methods, and evaluation results. This new approach improves clarity and accountability, making it easier for healthcare professionals to safely and effectively use these AI tools in their work. Who this helps: This helps patients and doctors by ensuring safer and more effective use of AI technology in cancer treatment.

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This study looked at how a specific particle, called the D^0 meson, is produced when heavy lead nuclei collide in a very specific way. Researchers found that they could measure these particles through certain events where one of the nuclei breaks apart while the other remains intact, and this was achieved using data from high-energy lead-lead collisions. Their findings help improve our understanding of how particles behave at a nuclear level, particularly in terms of the distribution of their constituent parts, showing important data about partons within lead nuclei. Who this helps: This helps physicists and researchers in particle physics who are studying nuclear interactions and fundamental particles.

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Researchers studied how the Higgs boson behaves when it decays into pairs of charm quarks and is produced alongside top quarks. They found that the rate of this occurrence is slightly lower than what the standard model predicts, with numbers showing an observed event rate of 0.91, and the charm-quark interactions better constrained at less than 3.5 times the standard model expectation. This matters because it helps scientists understand the fundamental properties of particles and how they interact, which is key for advancing physics knowledge. Who this helps: This research benefits physicists and researchers working on particle physics and the standard model.

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This study focused on analyzing three specific types of particles called B mesons: B^{*+}, B^{*0}, and B_{s}^{*0}. Researchers found the mass differences between these excited mesons and their normal counterparts to be very precise: 45.277 MeV for B^{*+}, 45.471 MeV for B^{*0}, and 49.407 MeV for B_{s}^{*0}. These findings are notable because they enhance the accuracy of our understanding of these particles by a factor of ten compared to earlier measurements. Who this helps: This helps physicists studying particle interactions and the fundamental forces in nature.

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The CMS particle detector at CERN observed, for the first time, a collision event in which a single top quark was produced alongside both a W and a Z boson simultaneously. The signal was confirmed with 5.8 standard deviations of statistical significance using 200 inverse femtobarns of data. This observation validates a predicted process in the Standard Model of particle physics and opens a new channel for probing fundamental interactions between quarks and force-carrying particles.

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This study looked at how using detailed information from a patient's previous scans can enhance the accuracy of automated systems that help define treatment areas in radiotherapy for rectal cancer. Researchers found that using this specific prior information led to significantly better results in auto-segmenting the treatment area, outperforming models that did not use this prior knowledge—achieving over 99% improvement in key metrics across two different centers. This is important because it means that treatment plans can be more accurate and effective, potentially leading to better outcomes for patients. Who this helps: This helps patients with rectal cancer who are receiving radiotherapy.

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This study examined the presence of mucoid bacteria in people with cystic fibrosis (CF) and how it relates to lung function. Researchers found mucoid bacteria in 9.1% of CF patients studied, and while overall lung function was similar between those with and without mucoid, women with mucoid showed significantly worse lung function. This matters because identifying mucoid could help improve treatments for CF patients, especially for those who are female or have certain bacterial infections. Who this helps: This helps patients with cystic fibrosis and their doctors.

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This study looked at how cannabis use and mental health issues like depression and anxiety changed over a year in 2,762 college students aged 18 to 25. It found that cannabis use dropped from 11.5% to 3.5% at one point and then rose again to 9.1%. Those with more mental health struggles were likely to have higher cannabis use, especially driven by impulsivity traits, highlighting the need for better support programs that help manage emotions for those at risk. Who this helps: This benefits college students who struggle with mental health issues and may be using cannabis.

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This study looked at how to improve radiotherapy for prostate cancer by adjusting treatment doses based on how much the tumor moves during therapy. Researchers found that using a zero margin approach, they could lower the radiation dose to surrounding healthy tissues by an average of 1.5 Gray, while still providing adequate coverage for the tumor in most cases. This method helps deliver more precise treatment, which is important for protecting healthy organs during radiation therapy. Who this helps: Patients receiving radiotherapy for prostate cancer.

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This study looked at how to better evaluate computer models that automatically identify and segment images of the male pelvis in MRI scans, especially when these models come from outside sources and the hospital doesn't have a large dataset for testing. The researchers developed a new method that uses data patterns to select images for testing, focusing on the more challenging and atypical cases rather than just randomly picking cases. This method improved the chances of identifying potential issue cases by 22% when selecting 20 cases, ensuring the model works well across different scenarios. Who this helps: This benefits doctors and medical facilities using these auto-segmentation models for better accuracy in patient imaging.

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This study looked at how showing doctors uncertainty maps from deep learning models affects their work when correcting MRI scans for prostate cancer radiation therapy. Researchers trained models on data from 434 patients and found that when oncologists had access to these uncertainty maps, they were able to make fewer edits, particularly in areas where the model was very confident, leading to a 14%-33% reduction in time spent on each patient's case. This matters because it supports doctors in making better decisions and improves the efficiency of cancer treatment planning. Who this helps: Patients undergoing prostate cancer treatment and their doctors.

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This study focused on improving how athletes are classified in handcycling, a sport in the Paralympics. Experts from various backgrounds reached an agreement on using upper-limb, shoulder, and lower-limb function to classify these athletes, but there was no agreement on the importance of trunk function, hand function, or equipment settings. This research is crucial because it helps ensure fair competition by making classifications more consistent and based on scientific evidence. Who this helps: This benefits athletes, coaches, and officials in the Paralympic handcycling community.

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This study looked at how often teenagers encounter alcohol-related content in digital media, like social media, and how this affects their thoughts and behaviors regarding drinking. Researchers tracked 302 high school students over three weeks, asking them to report their media exposure and complete surveys on their alcohol use. Initial findings will help create effective interventions to reduce underage drinking influenced by media. Who this helps: This research benefits teenagers and those working to reduce underage drinking.

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This research studied a genetically modified virus based on herpes simplex that can attack cancer cells while boosting the immune system's response. The virus, engineered to produce a protein called FLT3L, was effective in killing melanoma, glioblastoma, and pancreatic cancer cells, leading to increased immune activity. Specifically, the treated cancer cells showed growth inhibition and increased certain immune signals, highlighting the virus's potential as a new cancer treatment. Who this helps: This helps cancer patients, particularly those with melanoma, glioblastoma, and pancreatic cancer.

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This research looked at a group of tiny marine animals called Lagenopolycystis, specifically analyzing its known species and describing six new ones. The study found two existing species and introduced six new ones, highlighting differences in their male reproductive organ sizes and shapes. These findings are important for understanding biodiversity in marine habitats and can help scientists identify and classify these animals more accurately. Who this helps: This helps researchers studying marine biodiversity and conservation.

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This study focused on improving alcohol screening and treatment among people receiving HIV services in South Africa using a training method called "cascading train-the-trainer." Over two years, they trained 12 trainers who then taught 206 healthcare providers to use this method. As a result, nearly 42,000 clients were screened, 86% of those needing help received brief interventions, and just over half were referred for further treatment, showing the training was effective and reached many people. Who this helps: This benefits patients with HIV who may also be struggling with alcohol use, as well as the healthcare providers who support them.

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This study examined two strategies for implementing a behavioral treatment called contingency management (CM) in opioid treatment programs, which rewards patients for reaching their treatment goals. The enhanced strategy (E-ATTC) was found to significantly improve the use of CM among healthcare providers, with a 221% higher likelihood of exposure to CM and a 307% higher likelihood of reaching a high level of competency in delivering it compared to the standard approach (ATTC). Patients at clinics using the E-ATTC strategy were also twice as likely to remain abstinent from opioids over time. Who this helps: This helps patients with opioid use disorder by increasing access to effective treatment options.

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This study, called Project MIMIC, looked at how well two different strategies helped opioid treatment programs prepare to introduce a new method called contingency management to encourage patients in their care. Over the preparation period of five months, the more advanced strategy (E-ATTC) resulted in a faster completion rate of final preparation tasks, with providers completing these tasks 40% quicker than those in the standard strategy (ATTC). This matters because better preparation can lead to more successful treatment outcomes for patients with opioid use disorders. Who this helps: Patients receiving treatment for opioid addiction.

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This study looked at how a mobile app called Recovery Connect can help people with opioid use disorder stay in treatment longer. They found that 75.5% of patients using the app remained in treatment for 30 days, compared to 63.6% of those who didn’t use it. The results suggest that using this app leads to better treatment adherence and overall support for recovery. Who this helps: This benefits patients with opioid use disorder, helping them stay engaged in their treatment.

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This study looked for new particles that might exist alongside the Higgs boson by analyzing collisions of protons in a particle accelerator at a high energy level of 13 trillion electron volts. Researchers used advanced computer techniques to examine events where two gamma rays were produced together and found no signs of the predicted new particles. They were able to set limits on how often these particles could be produced, stating that for one of the particles, X, if it exists, its mass could range between 300 and 3000 GeV. Who this helps: This research benefits physicists studying fundamental particles and their interactions.

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This study looked at how the production of B+ mesons, a type of particle, is affected when protons collide with lead atoms at high energy. Researchers found that the number of B+ mesons produced stayed consistent across different levels of charged particles, meaning there were no significant changes in their production related to nuclear effects. This consistency helps scientists understand the role of nuclear environments in particle production, which is important for studying the fundamental interactions of matter. Who this helps: This benefits researchers in particle physics and helps advance our understanding of nuclear interactions.

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This study looked for rare particles that have charges less than a single electron charge in high-energy collisions between protons at a particle accelerator. Researchers analyzed data from over 138 million collisions and found no evidence of these fractionally charged particles, ruling out the existence of these particles with masses up to 640 billion electron volts and charges as low as one-third of an electron charge. This is important because finding such particles could change our understanding of fundamental physics. Who this helps: This helps physicists and researchers in the field of particle physics.

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This study looked at how machine-learning techniques can improve the way particle collisions are simulated and analyzed at the Large Hadron Collider (LHC). The researchers found that using machine learning to adjust existing simulations allows them to create more accurate models without having to run multiple costly simulations. This method is especially useful for accurately modeling complex events, like the production of top quark pairs, and will help improve measurements in future experiments. Who this helps: This benefits physicists and researchers working on particle physics experiments.

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This research looked for a heavy particle called the Z' boson, which may interact differently with other particles, specifically tau leptons and W bosons. Using data from particle collisions at the Large Hadron Collider, the researchers found no evidence of the Z' boson existing in mass ranges up to 2.45 TeV for tau decay and 1.60 TeV for W boson decay. This matters because it helps scientists refine their understanding of particle physics and the forces that govern how particles interact. Who this helps: This helps researchers and physicists studying fundamental particles and forces.

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This study looked at how particles behave in two types of collisions: proton-lead (pPb) and lead-lead (PbPb). Researchers found that in both collisions, high-energy particles showed similar patterns of using a measurement called elliptic anisotropy, especially when they produced a lot of charged particles. Specifically, they observed significant positive values for this measurement when the transverse momentum (energy) was above 8 GeV, indicating that these similarities suggest something fundamental about how these particles interact. Who this helps: This benefits physicists studying particle collisions and their fundamental properties.

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This study looked at how often two W particles and one Z particle are produced when protons collide at high energies at the CERN facility. They found that the production rates were about 75% of what scientists expected at 13 TeV, and 174% at 13.6 TeV, marking the first time they've been able to measure these processes separately. This research is important because it provides new insights into how these fundamental particles interact, which can enhance our understanding of the universe. Who this helps: This helps physicists and researchers studying particle physics.

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This study looked at a type of particle called charmonia, which consists of charm and anticharm quarks, to better understand how particles are produced in high-energy collisions of protons and lead. Researchers found that the ratio of two kinds of charmonia states—the excited state and the ground state—varies based on how many charged particles are present in the collision. Specifically, they observed a significant change in this ratio in certain conditions, which helps improve our understanding of particle interactions and production processes in such high-energy settings. Who this helps: This benefits researchers in particle physics and could improve methods for studying fundamental particles.

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This study investigated how gluons, which are particles that help hold protons and neutrons together, behave in heavy atomic nuclei during high-energy collisions. Researchers measured these gluons' properties in lead-lead (PbPb) collisions at a very high energy level of 5.02 TeV, discovering that at lower fractions of momentum, the reactions showed greater suppression than expected. These findings matter because they enhance our understanding of how gluons interact in dense matter, which can inform theories about nuclear physics and the structure of matter itself. Who this helps: This helps physicists and researchers studying the fundamental forces of nature.

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This study looked at how certain particles, called hyperons, are polarized (or aligned) in proton-lead collisions at a very high energy of 8.16 TeV. Researchers found that the degree of polarization changed based on the number of charged particles produced in the collision; specifically, polarization decreased as more charged particles were produced but increased when looking at higher momentum particles. These findings challenge existing theories about how spin polarization works in such high-energy collisions and provide new information about the underlying physics involved. Who this helps: This helps physicists and researchers studying particle interactions and the fundamental forces of nature.

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This study examined the patterns of jet production in events where multiple particles (leptons) are produced during high-energy collisions of protons. After analyzing a large amount of data from these collisions, the researchers found that the patterns matched what is expected from existing theories, showing no significant signs of new physics or unexpected jet production. Specifically, they looked at events with one, two, and four leptons and found no unusual increases in jet counts, which is important for understanding potential new particles predicted by theories beyond the current model. Who this helps: This helps researchers and physicists in their efforts to discover new particles and understand fundamental forces.

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This particle physics search for the rare decay of a D0 meson into two muons used 64.5 inverse femtobarns of proton-proton collision data from the CMS detector at the Large Hadron Collider. No significant signal was found, and the upper limit on the decay rate was set at 2.4 × 10^-9 — the tightest constraint ever placed on any flavor-changing neutral current decay in the charm quark sector. This result sets an important benchmark for testing extensions to the Standard Model of particle physics.

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This particle physics study reports the first observation of coherent phi(1020) meson photoproduction from heavy nuclei, using data from ultraperipheral lead-lead collisions at the Large Hadron Collider's CMS detector. The measured production cross section was about five times lower than a model treating the nucleus as a collection of free nucleons, consistent with nuclear shadowing effects that suppress gluon density in nuclei at low momentum fractions. The result provides a new tool for probing the internal gluonic structure of heavy nuclei at an energy scale bridging two regimes of quantum chromodynamics.

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This study examined two different strains of bacteria found in the intestines of a child who experienced diarrhea. Researchers identified one strain as Shiga toxin-producing and the other as a new variant of a common bacteria strain, showing that they were very similar genetically, with a 99.6% match in important sequences. This research matters because it reveals how bacteria can exchange genes within the gut, potentially affecting how they cause illness. Who this helps: This information benefits doctors treating patients with diarrhea, especially children, by improving understanding of bacterial infections.

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This study looked at how two different ways of defining a specific set of lymph nodes in breast cancer patients affected radiation treatment plans. Researchers found that the two definitions led to different treatment plans, with one method resulting in a higher average heart radiation dose (MHD of 1.07 Gy compared to 0.67 Gy). This is important because higher heart radiation could increase the risk of heart problems for patients after treatment. Who this helps: This helps breast cancer patients who may receive radiation therapy near the heart.

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This study looked for specific types of particles created when protons collide at a very high energy level. Researchers analyzed data from these collisions and found new evidence related to certain theoretical particles predicted by advanced physics models. This helps us better understand the behavior of particles at the smallest scales and narrows down possibilities for future discoveries in particle physics. Who this helps: This benefits physicists and researchers exploring advanced theories in particle physics.