DR. KENNETH M. MORRISON, MD

LANSING, MI

Research Active
Orthopaedic Surgery NPI registered 21+ years 50 publications 2024 – 2026 NPI: 1730185554
MiceSARS-CoV-2COVID-19Prostatic NeoplasmsEuropeInfluenza, HumanBrainEnvironmental ExposureRadiosurgeryInfluenza VaccinesEnvironmental PollutantsEcologyReceptors, Lysophosphatidic AcidPublishingPesticides

Practice Location

3394 E JOLLY RD
LANSING, MI 48910-8595

Phone: (517) 394-3200

What does KENNETH MORRISON research?

Dr. Morrison studies a wide range of health topics, including vaccines, cancer treatments, and the effects of environmental toxins. He has investigated how effective vaccines can be in preventing hospitalizations for respiratory virus infections in older adults and the effectiveness of cancer treatments that utilize novel compounds to target tumors better. Furthermore, his research also addresses environmental health concerns by examining the risks associated with certain pesticides and harmful chemicals that affect both humans and ecosystems. His work aims at improving health outcomes through better prevention strategies and treatment options.

Key findings

  • The RSVpreF vaccine lowered the hospitalization rate due to RSV by 75% in vaccinated older adults compared to those who were unvaccinated.
  • A new prostate cancer treatment method led to only 35% of patients experiencing side effects, with no serious complications reported after two years.
  • The introduction of boronotyrosine for boron neutron capture therapy showed improved tumor control with boron levels averaging 89.3 ppm in tumors, compared to 57.2 ppm with the traditional method.

Frequently asked questions

Does Dr. Morrison study vaccines?
Yes, Dr. Morrison researches vaccines, including their effectiveness against respiratory infections like RSV in older adults.
What treatments has Dr. Morrison researched?
He has researched cancer treatments, particularly focusing on innovative compounds used in boron neutron capture therapy to improve tumor targeting and control.
Is Dr. Morrison's work relevant to patients with childhood leukemia?
Yes, his research highlights the long-term health risks, such as increased belly fat and heart disease risk, faced by childhood leukemia survivors.
How does Dr. Morrison's work impact environmental health?
His studies on pesticides and PFAS chemicals provide critical insights into their health risks and the need for better regulation to protect both people and ecosystems.
What can pregnant women learn from Dr. Morrison's research?
Dr. Morrison's studies on gestational diabetes provide important information on the impact of elevated blood sugar levels on pregnancy outcomes, helping to guide better health practices.

Publications in plain English

The impacts of organochlorine pesticides on adverse human health outcomes: A second-order synthesis of mean effects and heterogeneity.

2026

Journal of hazardous materials

Morrison K, Ricolfi L, Yang Y, Mizuno A, Pollo P +2 more

Plain English
This study examined the health effects of organochlorine pesticides, which are chemicals linked to health problems even though many have been banned. The researchers analyzed 40 previous studies and found that exposure to these pesticides increased the chances of health issues by 28%. Specifically, compounds like DDE and HCH showed particularly strong links to diseases, with an increase in risk of 41% and 43%, respectively. This research highlights the ongoing dangers of these chemicals and underlines the need for continued monitoring and regulation. Who this helps: This benefits patients, health policymakers, and researchers focusing on environmental health.

PubMed

l‑Boronophenylalanine (l-BPA) Dipeptide Prodrugs Enhance Boron Delivery to Tumors, Facilitate Tumor Eradication and Induce Tumor Vaccine Effect in Mice Following Neutron Irradiation.

2026

ACS pharmacology & translational science

Torgov M, Raitano A, Quintana JC, Martin T, Kulenovic L +15 more

Plain English
Researchers studied new forms of a cancer treatment called boron neutron capture therapy (BNCT) to improve the delivery of boron to tumors in mice. They developed special compounds, dipeptides, that allowed them to use much higher doses of boron compared to the traditional treatment, resulting in complete tumor shrinkage in 56% of the cases treated, whereas the standard treatment only temporarily slowed tumor growth. This is important because it could lead to more effective cancer treatments that not only target the tumors better but also activate the immune system to fight cancer. Who this helps: This helps cancer patients by providing potentially more effective treatment options.

PubMed

Lateral full-endoscopic lumbosacral foraminotomy for foraminal stenosis in dogs: technique development and initial case series.

2026

Frontiers in veterinary science

Driver CJ, Morrison K, Sojak M, Rose J

Plain English
This study focused on a new surgical technique for treating degenerative lumbosacral stenosis (DLSS), a common cause of pain in dogs caused by pressure on spinal nerves. Researchers developed and tested a less invasive procedure called lateral full-endoscopic lumbosacral foraminotomy (LELF) in dogs, finding that it was successful without major complications. They observed a significant increase in the space around the nerves after surgery, with a CT scan showing the volume increasing from about 315 mm³ to 605 mm³, and many dogs reported less pain and improved quality of life after six months. Who this helps: This benefits dogs suffering from spinal nerve pain, as well as their owners and veterinarians looking for effective treatment options.

PubMed

Bivalent RSV prefusion vaccine effectiveness against hospitalisation in older adults: meta-analysis of case-control studies in England, Wales, Scotland, and Northern Ireland.

2026

The Lancet regional health. Europe

Bucholc M, Hameed SS, Cottrell S, Mensah AA, Morrison K +24 more

Plain English
Researchers studied the effectiveness of the RSVpreF vaccine in preventing hospitalizations due to respiratory syncytial virus (RSV) in older adults aged 74-79 in the UK during the 2024-25 RSV season. They found that 35% of the 11,117 hospitalized patients had received the vaccine, and overall, vaccinated individuals had a 75% lower chance of being hospitalized due to RSV compared to unvaccinated individuals. This is significant because it shows that the RSVpreF vaccine provides strong protection for older adults, who are particularly vulnerable to severe illness from RSV. Who this helps: This benefits older adults and healthcare providers by reducing hospitalizations from RSV.

PubMed

Lowering the Diagnostic Threshold for Gestational Diabetes: A Comparison of 2 Centres.

2026

Canadian journal of diabetes

Azizi S, Majdan A, Bond R, Garfield N, Meltzer S +5 more

Plain English
This study looked at how different diagnostic standards for gestational diabetes affect pregnancy outcomes in 840 pregnant women at two hospital centers in Montreal. Researchers found that women with mild hyperglycemia (a less severe form of high blood sugar) who didn't receive treatment were three times more likely to have larger babies than those who were treated for gestational diabetes based on higher glucose levels. This matters because not treating mild hyperglycemia can lead to complications during pregnancy and childbirth. Who this helps: This helps pregnant women and their healthcare providers understand the importance of monitoring and treating mild high blood sugar.

PubMed

Central Adiposity and Visceral Fat in Long-Term Survivors of Acute Lymphoblastic Leukemia in Childhood and Adolescence: Exploration of an Underappreciated Risk.

2026

Pediatric blood & cancer

Guolla L, Chou A, Farncombe TH, Thabane L, Morrison K +1 more

Plain English
This study looked at body fat distribution, specifically central obesity and visceral fat, in 70 long-term survivors of childhood acute lymphoblastic leukemia (ALL) who had been cancer-free for over ten years. The findings revealed that a significant portion of these survivors, 82.9%, had waist-to-height ratios indicating a high risk for cardiovascular problems, with 25.7% having dangerously high levels of visceral fat. This is important because it highlights that many survivors of childhood cancer may face increased risks for heart health issues, suggesting that routine checks for abdominal fat could help identify those at risk earlier. Who this helps: This helps childhood cancer survivors and their doctors.

PubMed

MATES: A tool for appraising the completeness with which a meta-analysis has been reported.

2026

Environment international

Morrison K, Pottier P, Pollo P, Ricolfi L, Williams C +34 more

Plain English
Researchers developed a new tool called MATES to help evaluate how thoroughly meta-analyses in environmental sciences are reported. They created a list of 14 important items to check in these studies, and testing showed that MATES can be reliably used, with an agreement rate of about 89% when evaluating its effectiveness in 50 meta-analyses. This tool matters because it improves transparency and helps ensure that meta-analyses provide accurate and useful information for researchers and policy-makers. Who this helps: This benefits researchers, editors, and anyone involved in environmental science studies.

PubMed

First estimation of the clinical utility of boronotyrosine as a boron delivery compound for boron neutron capture therapy in head and neck cancer.

2026

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Kilby W, Lee C, Morrison K, Capo L, Ikeura M +7 more

Plain English
This study examined a new compound called boronotyrosine (BTS) as a potential treatment for head and neck cancer using a method known as Boron Neutron Capture Therapy (BNCT). The research found that BTS could deliver more boron to tumors than the current standard treatment (boronophenylalanine) — with an average boron concentration in tumors of 89.3 parts per million (ppm) for BTS compared to 57.2 ppm for BPA. This improved delivery leads to better targeting of the cancer while reducing radiation exposure to healthy tissues, which is important for patient safety and treatment effectiveness. Who this helps: This benefits patients with head and neck cancer.

PubMed

Two-Year Outcomes of the SPARC Phase II Trial: Simultaneous Focal Boost With Stereotactic Radiation Therapy for Localized Prostate Cancer.

2026

International journal of radiation oncology, biology, physics

Yasar B, Suh YE, Chapman E, Nicholls L, Henderson D +9 more

Plain English
This study looked at a radiation therapy method called CyberKnife to treat localized prostate cancer by targeting the most affected area while trying to minimize side effects. Researchers found that two years after treatment, 35% of patients experienced some level of urinary issues, while only 5% had gastrointestinal problems, and there was no severe toxicity reported. Overall, quality of life remained stable, although sexual function did decline slightly for some men, showing the treatment is generally safe but may affect sexual health. Who this helps: This research benefits prostate cancer patients looking for effective treatment options with fewer side effects.

PubMed

Dragon Kill Points: applying a transparent working template to relieve authorship stress.

2026

BMC biology

Martinig AR, Burk SLP, Drobniak SM, Perry I, Morrison K +14 more

Plain English
This study looked at how to fairly manage authorship in academic research projects to reduce conflicts among contributors. The authors introduced a system called Dragon Kill Points, which helps track and recognize everyone's contributions based on five important principles. By implementing this system, research teams can reduce disagreements and ensure that all contributors are acknowledged, leading to a more inclusive and fair process. Who this helps: This helps researchers and academic institutions improve teamwork and recognition in collaborative projects.

PubMed

Attractor-Based Models for Sequences and Pattern Generation in Neural Circuits.

2026

Neural computation

Alvarez JL, Morrison K, Curto C

Plain English
This study investigated how certain brain networks, known as attractor-based networks, can create rhythmic patterns similar to those used for movement in animals. The researchers successfully designed a network that can alternate between five different walking patterns of a four-legged animal, showing how it counts and transitions between these movements. This discovery is important because it helps us understand how the brain organizes complex movements and rhythms, which could lead to better treatments for movement disorders. Who this helps: This helps patients with movement disorders and the doctors treating them.

PubMed

Influenza vaccine effectiveness from nine studies during drifted A(H3N2) subclade K predominance, Europe, September 2025 to January 2026.

2026

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Lucaccioni H, Marques DF, Kirsebom F, Emborg HD, Hamilton M +16 more

Plain English
This study looked at how effective the flu vaccine was during the 2025/26 season, when a particular version of the virus called A(H3N2) subclade K was widespread in Europe. Researchers found that the vaccine worked 25-45% of the time for all age groups, but it was more effective for children, with effectiveness rates between 47-72%. This is important because it shows that while the vaccine may not be perfect, it is still beneficial, and vaccination should continue alongside other ways to prevent the flu. Who this helps: This helps patients, especially children, and healthcare providers in managing flu outbreaks.

PubMed

Retraction Note: Influence of hypobaric hypoxia on leptin levels in men.

2025

International journal of obesity (2005)

Tschöp M, Strasburger CJ, Töpfer M, Hautmann H, Riepl R +7 more

PubMed

Characterisation of the bacteriomes harboured by major wireworm pest species in the Canadian Prairies.

2025

Insect molecular biology

Drahun I, Morrison K, Poole EA, van Herk WG, Cassone BJ

Plain English
This study looked at the bacteria living in wireworms, which are pests that harm crops in the Canadian Prairies. Researchers found that wireworms host over 400 types of bacteria, with a few key types making up most of these communities. Understanding these bacteria is important because it may lead to better ways to manage wireworm populations and protect crops. Who this helps: Farmers and agricultural scientists.

PubMed

Acute myeloid leukemia with peripheral lymph node involvement in dogs: A retrospective study of 23 cases.

2025

Veterinary pathology

Kaur J, Diamantino G, Morrison K, Meichner K, Springer NL +3 more

Plain English
This study looked at 23 dogs diagnosed with acute myeloid leukemia (AML) that also had swollen lymph nodes. The researchers found that many of these dogs, 78% to be exact, had low blood cell counts, and 69% of the dogs given treatment lived for at least 30 days. This research helps veterinarians identify AML more accurately when it affects lymph nodes, which can improve treatment decisions for affected dogs. Who this helps: This information benefits veterinarians and dog owners dealing with AML in pets.

PubMed

Coparenting Quality During COVID-19: Exploring Gender Differences Using a Mixed Methods Approach.

2025

Journal of family issues

Douglas S, Morrison K, Miller A, Haines J

Plain English
This study looked at how mothers and fathers coparented during the COVID-19 pandemic by comparing their experiences with a survey and open-ended questions. Although their overall coparenting scores were similar, fathers reported doing more tasks and supporting each other more, while mothers felt there was more conflict and undermining behavior. This matters because understanding these dynamics can help families navigate the stresses of parenting, especially during challenging times like the pandemic. Who this helps: This helps families improve their coparenting relationships during tough situations.

PubMed

AAHPM Assessment Workgroup: Hospice and Palliative Medicine Fellowship Assessment Needs and Directions.

2025

Journal of pain and symptom management

Ketterer B, Dingfield L, Stowers KH, Morrison K, Bailey A +5 more

Plain English
This study looked at how Hospice and Palliative Medicine (HPM) fellowship programs assess the skills and performance of their trainees. It found that nearly half of the program directors use four or fewer assessment tools, and while 83% of fellows felt confident in these tools, only 68% of directors did. The data revealed a significant lack of training and resources for program directors to effectively assess their fellows, highlighting a need for improved faculty development and collaboration with fellows in creating better assessment strategies. Who this helps: This benefits HPM program directors and training fellows, ultimately leading to better education and care for patients.

PubMed

Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications.

2025

Journal of neurology, neurosurgery, and psychiatry

Iacoangeli A, Dilliott AA, Al Khleifat A, Andersen PM, Başak NA +29 more

Plain English
This study looked at how having multiple rare genetic variants affects the risk of developing amyotrophic lateral sclerosis (ALS). The researchers found that about 6% of people with ALS have a higher risk of the disease if they carry several rare gene variants, compared to those with just one variant. However, having these multiple variants did not seem to affect how quickly the disease progresses or how long someone lives with ALS. Who this helps: Patients with ALS and their healthcare providers.

PubMed

Early evidence of RSV vaccination impact on hospitalisation rates of older people in Scotland.

2025

The Lancet. Infectious diseases

Hameed SS, Robertson C, Morrison K, McQueenie R, McMenamin J +2 more

PubMed

The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.

2025

The Journal of pharmacology and experimental therapeutics

Birker-Robaczewska M, Boucher M, Ranieri G, Poirey S, Studer R +20 more

Plain English
This study focused on a new drug called ACT-1016-0707 that targets a specific receptor involved in lung fibrosis, a serious lung disease. The researchers found that ACT-1016-0707 effectively prevents inflammation and scarring in various lab models, showing it works better than other similar drugs. This matters because fibrosis can lead to severe lung damage and breathing difficulties, and improving treatment options is crucial for patient care. Who this helps: This helps patients with pulmonary fibrosis and doctors seeking better treatment options for them.

PubMed

Location-Scale Meta-Analysis and Meta-Regression as a Tool to Capture Large-Scale Changes in Biological and Methodological Heterogeneity: A Spotlight on Heteroscedasticity.

2025

Global change biology

Nakagawa S, Mizuno A, Morrison K, Ricolfi L, Williams C +3 more

Plain English
This study focused on improving how scientists analyze changes in biological data by introducing a new method that looks at both average results and how varied those results are across different studies. The researchers found that by using their new approach, they could better understand shifts in biological responses to environmental changes, especially when considering factors like study design or environmental differences. This is important because it allows for clearer insights into how living systems respond to changes in their environment, which can guide conservation and management efforts. Who this helps: This helps researchers and conservationists understand the impacts of environmental changes on ecosystems.

PubMed

The impacts of pesticide exposure on fish conspecific interactions: A systematic review and meta-analysis.

2025

Environmental pollution (Barking, Essex : 1987)

Morrison K, Melhado G, Bose APH, Eastment R, Lagisz M +6 more

Plain English
This study looked at how exposure to pesticides affects social behavior among fish, focusing on interactions between fish of the same species. The researchers analyzed data from 37 studies involving 31 different pesticides and 11 fish species. They found that pesticide exposure generally reduces social interactions among fish, especially in courtship behaviors, which may lead to fewer successful breeding outcomes. Who this helps: This helps fish conservationists and environmental scientists understand the risks pesticides pose to fish populations and aquatic ecosystems.

PubMed

Diet quality in relation to serum perfluoroalkyl substance concentrations in Canadian preadolescents.

2025

Environmental research

Simpson A, Fisher M, Harrison S, Morisset AS, Borghese MM +7 more

Plain English
This study looked at the relationship between diet quality and levels of certain chemicals, known as perfluoroalkyl substances (PFAS), in the blood of Canadian children aged 7 to 11. They found that higher saturated fat in the diet was linked to increased levels of one type of PFAS (PFOS), while a higher protein intake was associated with lower levels of other types of PFAS like PFOA and PFOS. Understanding these relationships is important because PFAS exposure can lead to health issues, especially in young children whose bodies are still developing. Who this helps: This research benefits parents and healthcare providers who want to improve children's diets to reduce exposure to harmful chemicals.

PubMed

A Proposed Framework for an Interdisciplinary Food Allergy Immunotherapy Program for Pediatric Patients Transitioning to Adult Care.

2025

The journal of allergy and clinical immunology. In practice

Tong JY, Williams BA, Cameron SB, Chan ES, Cook VE +10 more

Plain English
This study looked at how to better support young people with food allergies as they move from pediatric to adult medical care. The researchers proposed a team approach that includes various specialists, like adult allergists and dietitians, to ensure these patients get comprehensive care tailored to their unique needs. This is important because a smooth transition will help young adults continue their immunotherapy treatment effectively and avoid serious allergic reactions as they grow older. Who this helps: This helps patients with food allergies transitioning to adult care and their healthcare providers.

PubMed

Ultrahypofractionated radiotherapy for localised prostate cancer: The impact of daily MRI-guided adaptive radiotherapy on delivered dose.

2025

Clinical and translational radiation oncology

Alexander SE, Mitchell RA, Dunlop A, Herbert T, Morrison K +4 more

Plain English
This study looked at a new type of radiation treatment for localized prostate cancer that uses MRI to adjust doses on a daily basis. Researchers found that patients receiving this MRI-guided therapy had a median dose of 40.3 Gy to their tumors, which is better than the 38.2 Gy given with standard treatment, meaning patients can receive a more accurate and effective dose while reducing harm to surrounding organs. This is important because it can lead to better cancer control while minimizing side effects, particularly for patients with higher risks or certain anatomical challenges. Who this helps: This helps prostate cancer patients, especially those with complex conditions or higher risks.

PubMed

Exploratory Rat Toxicology and Efficacy of the Boron Neutron Capture Therapy Drug Boronotyrosine in a Mouse Model of Head and Neck Cancer.

2025

International journal of radiation oncology, biology, physics

Raitano A, Kilby W, Morrison K, Capo L, Ikeura M +10 more

Plain English
Researchers studied a new treatment for head and neck cancer called Boronotyrosine (BTS), comparing it with the current standard treatment, Boronophenylalanine (BPA). They discovered that BTS not only worked better at sending medication to tumors but also had no harmful side effects even at high doses. For instance, BTS led to a reduction in tumor size after just 6 minutes of radiation, while the standard treatment showed less effectiveness and even tumor regrowth. Who this helps: This helps patients with head and neck cancer by offering a potentially more effective and safer treatment option.

PubMed

Harnessing meta-analyses' insights in ecology and evolution research.

2025

Royal Society open science

Pollo P, Martinig AR, Mizuno A, Morrison K, Pottier P +7 more

Plain English
This study looked at how researchers in ecology and evolution use and understand findings from meta-analyses, which are studies that combine results from multiple studies to get clearer insights. The researchers found that only about 21% of the articles published in 2023 cited meta-analyses, and when they did, they often ignored important details like the size of the effects and the limitations of the data. This matters because better understanding and citing meta-analyses can lead to stronger research and conclusions in these fields. Who this helps: This helps researchers and scientists in ecology and evolution.

PubMed

Evaluating participant experiences and tolerability with MR Linac imaging.

2025

Technical innovations & patient support in radiation oncology

Nartey J, McNair HA, Biscombe K, Alexander SE, Cherry C +10 more

Plain English
This study looked at how people feel during and after a type of cancer treatment known as MR Linac imaging, which uses MRI technology to guide radiation therapy. Out of 447 participants, 65% felt no anxiety before their scans, but those getting scans for head and neck issues reported higher anxiety and discomfort. This is important because understanding these experiences can help improve the process for patients, making it easier and more comfortable for them in the future. Who this helps: This helps patients undergoing MR Linac imaging, particularly those with head and neck conditions.

PubMed

Cup of Carbon: smartphone-based analysis of dissolved organic carbon in water for use in citizen science.

2025

The Analyst

Muir MR, Bass AM, Galt K, Morrison K, Robertson L +1 more

Plain English
The study looked at a simple and affordable way for people to measure the amount of dissolved organic carbon (DOC) in water by using a white mug, a piece of laminated white paper, and a smartphone camera. Researchers found that this method provided DOC concentration estimates that were close to those from more complex lab equipment, with a difference of about 8.2% on average. This matters because it makes it easier for everyday people to participate in monitoring water quality, especially in areas where expensive equipment isn't available. Who this helps: This helps citizens, educators, and environmental groups interested in water quality.

PubMed

Unravelling the magnitude and drivers of PFAS trophic magnification: a meta-analysis.

2025

Nature communications

Ricolfi L, Yang Y, Pottier P, Morrison K, Williams C +6 more

Plain English
This study looked into how harmful chemicals known as PFAS (often found in various products) build up in food chains, affecting both ecosystems and potentially human health. Researchers analyzed data from 119 food webs and found that, on average, the concentration of PFAS doubles with each step up the food chain, meaning the top predators can have much higher levels of these substances. For instance, one specific PFAS, called F-53B, showed even higher magnification, suggesting it accumulates more than others, which raises concerns since it is increasingly used without much regulation. Who this helps: This information benefits environmental scientists, policymakers, and communities concerned about ecological and human health risks from PFAS.

PubMed

Evaluation of the delivery of the family nurse partnership programme in Scotland during the COVID-19 pandemic.

2025

PloS one

Doi L, Morrison K, Anago EK, Hughes T

Plain English
This study looked at how the Family Nurse Partnership (FNP) program in Scotland adapted to using telehealth services during the COVID-19 pandemic. Researchers found that 42% of family nurses preferred a mix of face-to-face and remote support for future FNP delivery, despite some challenges in building relationships and recruiting clients with complex needs. This is important because it shows that remote services can effectively support young mothers, particularly those who felt isolated during the pandemic, and suggests a flexible approach could benefit many clients moving forward. Who this helps: This helps first-time young mothers and family nurses providing support.

PubMed

Caveats in reporting of national vaccine uptake.

2024

Journal of global health

Millington T, Morrison K, Jeffrey K, Sullivan C, Kurdi A +10 more

PubMed

Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold.

2024

Journal of medicinal chemistry

Lescop C, Brotschi C, Williams JT, Sager CP, Birker M +5 more

Plain English
This study focused on a new potential treatment for diseases involving excessive tissue scarring, known as fibrosis, by targeting a specific receptor (LPAR1) in the body. Researchers found a compound that effectively blocks this receptor, showing promise in lab tests, particularly in preventing skin leakage in mice. This is important because it could lead to new medications that help alleviate conditions related to fibrosis, benefiting many patients. Who this helps: This helps patients with fibrotic diseases and their doctors.

PubMed

Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases.

2024

Journal of medicinal chemistry

Lescop C, Birker M, Brotschi C, Bürki C, Morrison K +4 more

Plain English
Researchers developed a new drug called ACT-1016-0707, which effectively blocks a specific receptor (LPA1) involved in fibrotic diseases, conditions where tissue becomes thick and stiff. In tests, this drug was found to be more stable and easier for the body to use compared to earlier versions, potentially making it a strong candidate for treating these diseases. This matters because effective treatments for fibrotic diseases are limited, and this new drug could offer a better option for patients. Who this helps: Patients suffering from fibrotic diseases.

PubMed

A systematic evidence map and bibliometric analysis of the behavioural impacts of pesticide exposure on zebrafish.

2024

Environmental pollution (Barking, Essex : 1987)

Morrison K, Yang Y, Santana M, Lagisz M, Nakagawa S

Plain English
This study looked at how exposure to pesticides affects the behavior of zebrafish, a common model organism in environmental science. Researchers found that many important pesticides, like neonicotinoids, haven't been thoroughly studied, and that many past studies didn't share key details about the zebrafish used, such as their sex and age. Understanding these factors is crucial because it helps shape future research and can lead to better policies for protecting aquatic life. Who this helps: This helps researchers and policymakers focused on environmental safety and conservation.

PubMed

Safety and Effectiveness of Bypassing Oral Immunotherapy Buildup With an Initial Phase of Sublingual Immunotherapy for Higher-Risk Food Allergy.

2024

The journal of allergy and clinical immunology. In practice

Soller L, Williams BA, Mak R, Wong T, Erdle SC +5 more

Plain English
This study looked at a treatment called sublingual immunotherapy (SLIT) for children aged 4 to 18 with food allergies, particularly those at higher risk if they used a different treatment called oral immunotherapy (OIT). Among the 188 patients treated, only 4 (about 2%) had to use epinephrine for allergic reactions, and 70% of a smaller group successfully passed a food challenge after starting with SLIT, thus avoiding the more dangerous OIT buildup. This matters because it shows that SLIT is a safer option for these higher-risk patients and can be effective in helping them manage their food allergies. Who this helps: This helps children with food allergies and their families by providing safer treatment options.

PubMed

Exercising medical judgement: resuscitation and "Decision-Making for End-of-Life Care," a new policy from the College of Physician and Surgeons of Ontario.

2024

Canadian journal of anaesthesia = Journal canadien d'anesthesie

Ajzenberg H, Connolly E, Morrison K, Oczkowski S

Plain English
In March 2023, the College of Physicians and Surgeons of Ontario changed its policy on end-of-life care, shifting from a requirement for doctors to perform CPR unless a patient specifically says not to, to a more flexible approach where doctors can decide not to perform treatments they believe won't help the patient. This change aligns with a 2019 court ruling that emphasizes offering only treatments that are beneficial. The new policy is important because it acknowledges the need for more thoughtful decisions in end-of-life care, which could prevent unnecessary suffering for patients. Who this helps: This helps patients and their families navigating end-of-life decisions.

PubMed

Simultaneous Focal Boost With Stereotactic Radiation Therapy for Localized Intermediate- to High-Risk Prostate Cancer: Primary Outcomes of the SPARC Phase 2 Trial.

2024

International journal of radiation oncology, biology, physics

Yasar B, Suh YE, Chapman E, Nicholls L, Henderson D +9 more

Plain English
This study looked at a new way to treat localized prostate cancer using a type of focused radiation therapy called CyberKnife. Twenty patients received a special dose of radiation that was higher in the areas of most concern, and the results showed that 25% of them experienced mild urinary side effects, while 30% had mild gastrointestinal issues. Importantly, no patients had serious long-term side effects, and none showed signs of cancer returning after treatment. Who this helps: This benefits patients with high-risk localized prostate cancer.

PubMed

Incidence, management and prognosis of new-onset sarcoidosis post COVID-19 infection.

2024

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG

Vij O, Dey M, Morrison K, Kouranloo K

Plain English
This study looked at the connection between COVID-19 and the development of a condition called sarcoidosis, which involves inflammation in various organs. Researchers found 15 patients diagnosed with sarcoidosis after having COVID-19, with an average age of about 46 years, and a diagnosis occurring roughly 56 days after the COVID-19 infection. This is important because it highlights a possible link between COVID-19 and a new risk of sarcoidosis, which can affect the lungs and other organs, leading to serious health issues. Who this helps: This research benefits patients who have recovered from COVID-19, doctors monitoring their long-term health, and those at risk of autoimmune conditions.

PubMed

Clinical case report of intractable paroxysmal sympathetic hyperactivity in TANGO2 deficiency disorder.

2024

American journal of medical genetics. Part A

Morrison K, Koshiya H, Safier R, Brown A, May C +2 more

Plain English
This study looked at a person with TANGO2 deficiency disorder, a rare neurodegenerative disease, who experienced severe episodes of uncontrolled sympathetic nervous system activity, known as paroxysmal sympathetic hyperactivity (PSH). Despite thorough investigations, doctors couldn't find a specific cause for these episodes, and treatments did not work, leading to a focus on providing comfort instead. This finding highlights that PSH can occur in patients with TANGO2 deficiency, indicating a need for more research to improve treatment options for the disorder. Who this helps: Patients with TANGO2 deficiency disorder and their healthcare providers.

PubMed

Measurement and Incorporation of Laryngeal Motion Using cine-MRI on an MR-Linear Accelerator to Generate Radiation Therapy Plans for Early-stage Squamous Cell Cancers of the Glottis.

2024

Advances in radiation oncology

Gupta A, McQuaid D, Dunlop A, Barnes H, Mohajer J +11 more

Plain English
This study looked at how the larynx (voice box) moves when people swallow and breathe, using special MRI technology to help improve radiation therapy plans for patients with early-stage throat cancer. Researchers found that the larynx moves mostly up and down, and while swallowing is infrequent, accounting for the larynx's resting motion is enough to create effective treatment plans. Importantly, using advanced radiation techniques can lower the amount of radiation exposure to nearby organs like the carotid arteries, which may reduce the risk of complications in the future. Who this helps: This helps cancer patients undergoing radiation therapy, as it aims to improve treatment safety and effectiveness.

PubMed

Development of an outcome indicator framework for a universal health visiting programme using routinely collected data.

2024

BMC health services research

Horne M, Marryat L, Corby DH, Doi L, Astbury R +3 more

Plain English
This study looked at how to measure the success of a new health visiting program in Scotland that has been helping families with young children since 2016. Researchers developed 18 indicators that track various child health outcomes, such as vaccination rates (93.6% of kids had all their shots by age two) and obesity rates (with only 63.2% having their BMI recorded by age two and a half). Understanding these outcomes matters because it helps improve support for families, ensuring children get a good start in life. Who this helps: This benefits children and their families by providing better healthcare support.

PubMed

MedSyn: Text-Guided Anatomy-Aware Synthesis of High-Fidelity 3-D CT Images.

2024

IEEE transactions on medical imaging

Xu Y, Sun L, Peng W, Jia S, Morrison K +5 more

Plain English
This study developed a new method to create high-quality, 3D images of lungs using text descriptions to guide the process. The researchers found that their approach, using a special model, performed better than previous techniques, particularly in capturing important lung details like fissures and airways. This matters because clearer and more accurate CT images can improve medical diagnoses and treatments. Who this helps: Patients and doctors who rely on precise imaging for lung health.

PubMed

Fingerprinting DNAzyme Cross-Reactivity for Pattern-Based Detection of Heavy Metals.

2024

Analytical chemistry

Morrison K, Tincher M, Rothchild A, Yehl K

Plain English
This research studied how to detect heavy metals like lead in food and water using specialized sensors made from DNA. The scientists created a set of four DNA sensors to improve accuracy and found that their method could identify and measure different metals, even in mixtures, with lead detection capabilities as low as a tiny fraction of a part per million. This is important because it can help reduce exposure to toxic metals in our environment. Who this helps: Patients and communities concerned about heavy metal contamination in their food and water.

PubMed

Title, abstract and keywords: a practical guide to maximize the visibility and impact of academic papers.

2024

Proceedings. Biological sciences

Pottier P, Lagisz M, Burke S, Drobniak SM, Downing PA +10 more

Plain English
This research paper studied how to make academic articles more visible online by examining 230 journals in the ecology and evolutionary biology fields. The findings showed that many authors do not effectively use key terms in their titles and abstracts, with 92% using repetitive keywords, which makes it harder for people to find their work. The researchers suggest making changes to journal guidelines to help researchers better reach their audience, such as allowing longer abstracts and using structured formats. Who this helps: This helps authors and researchers by making their work easier to find and read.

PubMed

Selecting the most informative positive and negative controls for self-controlled case series (SCCS): Rationale, approach, and lessons from studies investigating the safety of COVID-19 vaccines.

2024

Journal of global health

Rudan I, Katikireddi SV, Kerr S, Millington T, Grange Z +10 more

PubMed

Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study.

2024

The Lancet. Respiratory medicine

Meslé MMI, Brown J, Mook P, Katz MA, Hagan J +62 more

Plain English
This study examined how many lives were saved by COVID-19 vaccinations across 54 European countries from December 2020 to March 2023. The researchers found that vaccinations reduced deaths by 59% overall, saving about 1.6 million lives, with 96% of those saved being people aged 60 and older. This research highlights the critical role of vaccines, especially first booster doses during the Omicron wave, in protecting older adults from severe illness and death. Who this helps: This helps older adults and public health officials focus on vaccination efforts.

PubMed

Drivers and Impacts of the Record-Breaking 2023 Wildfire Season in Canada.

2024

Nature communications

Jain P, Barber QE, Taylor SW, Whitman E, Castellanos Acuna D +13 more

Plain English
The 2023 wildfire season in Canada was the worst ever, burning about 15 million hectares of forest from April to October. This was largely due to early snowmelt, ongoing drought in the west, and rapid drying out in the east, all made worse by climate change, which raised temperatures by 2.2°C compared to previous years. The wildfires led to over 200 communities being evacuated and put immense strain on firefighting efforts, showing just how serious and frequent wildfires may become in the future. Who this helps: This helps communities, firefighters, and policymakers who need to prepare for and respond to wildfires.

PubMed

Increasing Accessibility to Intradialytic Cycling in Rural and Remote Settings: Program Report.

2024

Canadian journal of kidney health and disease

Erian S, Davies R, Morrison K, West C, Ruiz M +3 more

Plain English
This study focused on making exercise more accessible for people undergoing hemodialysis (HD) in rural and remote areas. Researchers created a virtual program for intradialytic cycling (IDC) to help improve symptoms like leg cramps and depression, but they found that only 22% of the targeted dialysis units adopted the program, falling short of the goal of 30%. Despite this, the program showed potential to help patients improve their quality of life and physical fitness. Who this helps: This benefits patients on dialysis who struggle with exercise options in remote areas.

PubMed

Potential of APSIS-InSAR for measuring surface oscillations of tropical peatlands.

2024

PloS one

Ledger MJ, Sowter A, Morrison K, Evans CD, Large DJ +4 more

Plain English
This study tested whether a satellite radar technique called APSIS-InSAR can detect the seasonal swelling and shrinking of tropical peat soils under dense forest in Malaysia. The radar signal penetrated the forest canopy well enough to measure surface movement at 20-meter resolution across the landscape. The approach could enable continuous, large-scale monitoring of peatland degradation — a major source of carbon emissions — that is currently very difficult to measure on the ground.

PubMed

Frequent Co-Authors

Yefeng Yang Malgorzata Lagisz Shinichi Nakagawa Lorenzo Ricolfi Ayumi Mizuno Pietro Pollo Coralie Williams Patrice Pottier Chris Robertson April Robin Martinig

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.