Ascorbic acid and paraquat: oxygen depletion with concurrent oxygen activation.
1982Toxicology and applied pharmacology
Montgomery MR, Furry J, Gee SJ, Krieger RI
PubMedDR. JOHN M. FURRY, MD
DECATUR, IL
Pain Medicine - Interventional Pain Medicine NPI registered 21+ years 2 publications 1981 – 1982 NPI: 1245237304
Pain Medicine - Interventional Pain Medicine Anesthesiology - Pain Medicine Anesthesiology - Pain Medicine Surgery Surgery Anesthesiology - Pain Medicine Anesthesiology Anesthesiology
LiverMiceGlucoseRatsRats, Inbred StrainsEnergy MetabolismMice, Inbred BALB COxygen ConsumptionDrug SynergismBleomycinSuperoxide DismutaseAscorbic AcidDimethyl SulfoxideParaquatMixed Function Oxygenases
What does JOHN FURRY research?
Dr. John M. Furry studies the impact of the chemotherapy drug bleomycin on the liver's ability to function effectively. His research involves testing on mice and rats to determine how bleomycin affects the liver's processes, specifically looking at how well the liver can break down substances. This work is crucial for understanding potential side effects of bleomycin in cancer treatment, particularly related to liver function, which is vital for processing medications and toxins.
Key findings
- One dose of bleomycin in animal models reduced the liver’s ability to break down ethylmorphine after four days.
- Repeated doses of bleomycin lowered liver enzyme activity and cytochrome P450 levels in both mice and rats.
- Intraperitoneal (administered into the body cavity) injections affected rats but did not show the same impact on mice when it came to liver enzyme levels.
Frequently asked questions
- Does Dr. Furry study liver diseases?
- Yes, Dr. Furry's research focuses on liver function, particularly how it is affected by the drug bleomycin.
- What treatments has Dr. Furry researched?
- Dr. Furry has specifically researched the chemotherapy drug bleomycin and its effects on liver function.
- Is Dr. Furry's work relevant to cancer patients?
- Yes, his work is relevant as it helps understand the potential side effects of bleomycin, particularly regarding liver health in cancer treatment.
Publications in plain English
Bleomycin inhibits hepatic mixed function oxidation.
1981Research communications in chemical pathology and pharmacology
Montgomery MR, Furry J, Fernandez S
Plain English
This study looked at how a drug called bleomycin affects liver function in mice and rats. Researchers found that just one dose of bleomycin reduced the liver's ability to break down a substance called ethylmorphine after four days. Specifically, in tests with repeated doses, they noticed that subcutaneous injections lowered both the liver enzyme activity and the amount of a protein called cytochrome P450 in both mice and rats, while intraperitoneal injections only affected rats.
Who this helps: This information can help doctors better understand the effects of bleomycin on liver function in their patients.
Frequent Co-Authors
M R Montgomery S J Gee R I Krieger S Fernandez
Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.