DR. JEFFREY MICHAEL NASSIF, MD

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This research paper looks at how implant-supported overdentures (ISODs) can improve the quality of life for people who no longer have their teeth. It finds that using just two implants for lower dentures (mandibles) is highly recommended because it makes the dentures more stable and easier to use. For upper dentures (maxillas), at least four implants are usually needed due to space issues. The paper emphasizes the importance of choosing the right attachment systems for these implants to ensure better function and reduce complications over time. Who this helps: This benefits patients who are getting dentures, offering them better options for comfort and stability.

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This study explored differences in brain structure, specifically in the supplementary motor cortex (SMC), among three types of Parkinson's Disease (PD) patients: those whose main symptoms include tremors, those with postural instability and gait difficulty, and those with stiffness and slowness. It found that the volume of grey matter in the SMC was significantly different between women with tremor-dominant PD and those with postural instability. Understanding these differences is important for improving how PD is classified and treated, especially since symptoms can vary based on sex and motor subtype. Who this helps: This helps patients and doctors by providing more accurate ways to understand and manage Parkinson's Disease.

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Researchers studied how to improve training for radiochemists, which is important for jobs in energy, medicine, and national security. They created a new graduate certificate program at the University of Iowa that uses both online and hands-on training. From Fall 2024 to Summer 2025, 12 participants completed this program successfully, showing a strong demand for this type of education. Who this helps: This benefits students and professionals in the radiochemistry field looking for effective training opportunities.

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This study looked at how to improve human biomonitoring (HBM), which measures chemical exposure in people, by creating clear guidelines for what information should be collected and reported. Researchers found that having agreed-upon standards, known as Minimum Information Requirements for Human Biomonitoring (MIR-HBM), would make studies more reliable and useful for understanding chemical risks. Implementing these guidelines can help protect public health by providing better data for policymakers. Who this helps: This benefits patients and health professionals working to assess and manage chemical exposure risks.

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This research looked at how multidisciplinary teams (MDTs) can improve care for patients with endometriosis and adenomyosis. From their survey of 69 health professionals, they found that nearly half had MDT meetings, but only about 25% of patients were discussed in these meetings. They created 82 recommendations to help make these meetings more effective, achieving a strong agreement of 92.7% on the importance of personalized care through MDTs. Who this helps: This benefits patients by promoting better, coordinated treatment for endometriosis and adenomyosis.

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This study introduced a new online tool called the HB2GV Dashboard, which serves as a central resource for health-based guidance values related to human biomonitoring data, helping people find information on environmental chemicals more easily. Researchers created this tool to address the lack of a single database, making it easier for public health professionals and decision makers to access important health information quickly. This is significant because it supports better public health decisions by providing clear guidance on how exposure to various chemicals can affect health. Who this helps: This helps public health professionals, researchers, and regulatory bodies who need to assess the health impacts of chemical exposures.

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This research paper looks at how certain cellular processes contribute to endometriosis, a condition where tissue similar to the lining of the uterus grows outside it, often causing pain and infertility. The study found that two key signaling pathways, mTOR and AMPK, are disrupted in endometriosis, leading to increased cell growth and stress in the cells, as well as mitochondrial dysfunction which boosts energy production and causes harmful byproducts. Understanding these changes can help develop better diagnostic and treatment options for endometriosis. Who this helps: This helps patients suffering from endometriosis and their doctors.

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This study looked at the risk of mesh erosion—a complication that can occur after pelvic surgery—when performing two types of hysterectomy during a procedure called abdominal sacrocolpopexy. Researchers analyzed 19 studies involving over 10,500 women and found that only 0.36% of women who had a supracervical hysterectomy experienced mesh erosion, compared to 3.8% of women who underwent a total hysterectomy. This is significant because it indicates that the supracervical approach has a much lower risk of this complication. Who this helps: This research benefits women undergoing pelvic surgery, particularly those with pelvic organ prolapse.

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This study looked at how sexual addiction is viewed in both medicine and law. Researchers found a lack of consensus on whether sexual addiction is a real mental health diagnosis, with some legal cases accepting it as a reason for reduced blame while others did not due to insufficient evidence. This is important because it raises questions about how sexual behavior is understood and treated in both clinical and legal settings. Who this helps: Patients dealing with sexually compulsive behaviors and legal professionals.

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This study looked at the National Biomonitoring Network (NBN), which was established to improve how the U.S. monitors human exposure to chemicals. Since 2018, the NBN has united 20 state public health laboratories to standardize data practices, enhance training, and provide technical assistance. This is important because it helps ensure high-quality data that can lead to better public health decisions and policies. Who this helps: This benefits public health officials and researchers who track chemical exposures to improve community health.

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This study compared the effectiveness of two treatments for pelvic pain caused by endometriosis: dienogest, a type of hormonal treatment, and the combined oral contraceptive pill (Yasmin). After 24 weeks of treatment, both options significantly reduced average pelvic pain scores, with dienogest showing a 6-point improvement and Yasmin a 4.54-point improvement on a scale used to measure pain. However, dienogest had fewer side effects and was better tolerated than Yasmin, making it a promising option for managing this condition. Who this helps: This research benefits women suffering from endometriosis by providing effective treatment options with fewer side effects.

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This study looked at whether positioning patients in a specific way after gynecological laparoscopic surgery could reduce shoulder pain. Researchers found that patients who were placed in a Trendelenburg position (head down) for 24 hours after surgery had much lower pain scores at 12 hours post-op compared to those who were put in a regular position. Specifically, pain scores were nearly zero for the Trendelenburg group versus 5 for the control group, showing a significant improvement. Who this helps: This benefits patients undergoing gynecological laparoscopic procedures by reducing their postoperative shoulder pain.

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This study examined a new way to teach medical students how to perform breast examinations by using a hybrid method that combines a standardized patient with a silicone breast simulator. The research involved 82 third-year medical students, and it found that while both teaching methods had similar scores for overall exam completeness, those using the hybrid model were significantly better at identifying issues (scores improved with a p-value of less than 0.001) and reported feeling more confident and satisfied with their learning experience. This matters because better training can lead to more accurate examinations, ultimately improving patient care. Who this helps: This helps medical students and their future patients.

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The study focused on how well pelvic ultrasounds can diagnose a condition called adnexal torsion, which often occurs in women of childbearing age. Researchers found that ovarian enlargement is a key sign that suggests torsion is present, while ovarian swelling is the most reliable indicator. Identifying these signs accurately is crucial because it can lead to faster and more effective treatment. Who this helps: This helps doctors and medical professionals who diagnose and treat women with reproductive issues.

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This study looked at how people's religious backgrounds affect their views on choosing the sex of babies before they are born, using a survey completed by 1,500 participants at a health center in Beirut. The results showed that 19% of respondents felt that selecting a baby's sex was completely wrong, 38.8% thought it was acceptable only for medical reasons, and 33.4% believed it should be available to anyone who wants it. The findings reveal that religious beliefs, education, and existing children's genders play a big role in shaping these attitudes in the Middle Eastern population, which generally has a negative view on sex selection. Who this helps: This helps patients and families considering sex selection, as well as healthcare providers addressing their concerns.

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This study looked at different ways to close the abdominal wall after laparoscopic surgery, which is a minimally invasive procedure that has become very popular due to quicker recovery and increased patient satisfaction. The researchers focused on preventing complications, particularly hernias that can occur at the insertion sites, by improving closure techniques. Properly closing these sites is important because it can lead to better recovery outcomes and fewer complications for patients. Who this helps: Patients undergoing laparoscopic surgery.

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Researchers studied the levels of harmful chemicals called PFAS in people from a New Hampshire community that had contaminated drinking water from an old Air Force base. They found that over 94% of the 1,578 individuals tested had detectable levels of three specific PFAS chemicals, with average concentrations much higher than those typically found in the general U.S. population: 8.6 µg/L for PFOS, 3.1 µg/L for PFOA, and 4.1 µg/L for PFHxS. This matters because it highlights the significant health risks posed by PFAS exposure and the need for a national effort to monitor and address the contamination. Who this helps: This helps affected community members and public health officials.

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This study examined a young woman with an ovarian cystic teratoma who also had a severe blood disorder called immune thrombocytopenia, where she had very low platelet counts. After surgically removing the teratoma, her blood condition completely resolved, marking the second known case linking these two conditions. Understanding this connection is crucial as it could lead to better treatments for similar patients in the future. Who this helps: This helps patients with immune thrombocytopenia, particularly those with ovarian teratomas.

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This study looks at the need for a coordinated system in the U.S. to monitor how chemicals in the environment affect people's health. It found that without a national network, there's a inconsistent understanding of chemical exposure across states, making responses to health crises less effective. Establishing a National Biomonitoring Network will allow better tracking of chemical exposure and improve public health responses, ensuring that data on harmful chemicals is consistent and useful for protecting people's health. Who this helps: This helps patients, public health officials, and policymakers by providing better data for health decisions.

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This study looked at a rare heart condition called Takotsubo cardiomyopathy, which can occur during laparoscopic myomectomy surgeries when epinephrine is used to control bleeding. The researchers reported a specific case where a patient developed this heart issue because of the epinephrine injection, highlighting that the condition is often mistaken for a heart attack. This matters because it emphasizes the need for better awareness of the risks linked to using epinephrine during such procedures, especially for female patients who may be more affected. Who this helps: This helps doctors and patients undergoing laparoscopic myomectomy by providing important safety information.

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This study looks at a case involving a large Nabothian cyst, a common but usually harmless cyst that can sometimes be mistaken for cancer. The patient, a 44-year-old woman, had an 8 cm cyst found through ultrasound and MRI, and it was successfully removed with a minimally invasive procedure, enabling her to recover quickly without needing a more aggressive surgery like a hysterectomy. This matters because accurate diagnosis and treatment of these cysts can prevent unnecessary surgeries and reduce recovery time for patients. Who this helps: Patients with Nabothian cysts and their doctors.

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This study looked at how effective botulinum toxin type A (BTX-A) is for treating knee flexion contracture (KFC), a common issue for people with hemophilia where the knee cannot straighten properly. Seventeen patients with a total of 21 affected knees were treated, and on average, their knee angle improved by 14 degrees over a year, which significantly increased their ability to perform daily activities. This is important because improved knee function can reduce disability and enhance mobility for those affected. Who this helps: This benefits patients with hemophilia who experience knee issues.

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This study looked at two patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a condition where women are born without a uterus and part of the vagina. The researchers used a new, less invasive surgery called the laparoscopic modified Vecchietti technique to create a functional vagina for both patients, showing it worked well with fewer complications and less time needed for the operation. This matters because it provides a better option for women with MRKH syndrome to lead a more normal life. Who this helps: This helps women with MRKH syndrome.

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This study looked at how certain molecules in the body, called reactive oxygen species (ROS), play a role in the development of endometriosis, a condition where tissue similar to the lining of the uterus grows outside it, causing pain and infertility. Researchers found that endometriotic tissues had higher levels of ROS and specific proteins related to their growth, showing that these molecules contribute to the disease's progression. This matters because understanding these mechanisms could lead to new treatments that help manage pain and improve fertility for those affected by endometriosis. Who this helps: Patients with endometriosis and their healthcare providers.

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This study looked at how to best use cryopreserved human amniotic membrane (HAM) to prevent scar tissue (adhesions) after surgery in mice. It found that using HAM in small pieces dissolved in a solution significantly reduced the formation of adhesions, with the application leading to fewer adhesions than both using the HAM as a patch and leaving the abdominal cavity without treatment. Specifically, using the fragmented HAM resulted in a significant reduction in postoperative adhesion rates compared to other methods. Who this helps: This research benefits patients undergoing abdominal surgeries by potentially reducing their risk of complications related to adhesions.

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This study looks at Raynaud's phenomenon (RP), a condition where cold temperatures cause blood vessels to constrict too much, leading to color changes and discomfort in fingers and toes. Researchers found that this reaction is influenced by the sympathetic nervous system and the hormone estrogen, explaining why RP is more common in younger women than in men of the same age. Understanding these factors is important for developing better treatments, as current options vary in effectiveness and more research is needed to find reliable solutions. Who this helps: This information benefits patients with Raynaud's phenomenon and their doctors.

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This study looked at how low iron levels (preoperative anaemia) and blood transfusions affect recovery after gynecological surgery in nearly 13,000 women. Researchers found that 23.9% of the women had preoperative anaemia, which was linked to a 2.4 times higher risk of dying within 30 days after surgery and an 80% increased risk of experiencing serious complications. Blood transfusions did not adequately reduce these risks. Who this helps: This research benefits doctors and healthcare providers by highlighting the importance of managing anaemia in women before surgery to improve their outcomes.

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This study focused on a rare and serious complication of pregnancy involving a cerebral aneurysm that can lead to bleeding in the brain. In this case, a 38-year-old woman who was 36 weeks pregnant experienced severe bleeding but successfully underwent an emergency cesarean section, followed by treatment for her aneurysm. Both the mother and baby left the hospital in good health, although the mother developed a language issue due to the brain injury. Who this helps: This research benefits pregnant women with cerebral aneurysms and their medical teams.

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This study focused on a rare condition called congenital vesicovaginal fistula, where there is an abnormal connection between the bladder and vagina, leading to urinary issues. The researchers examined two young women who had painful symptoms and were diagnosed with this condition, revealing they both also had other reproductive system issues. Out of 23 previously reported cases in literature, 74% experienced menstrual flow problems, which shows that this condition can have significant implications for women's health. Who this helps: This helps doctors and patients dealing with rare reproductive system issues.

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This study looked at a rare case of a woman who became pregnant with twins for the second time after taking a medication called clomiphene citrate to help her ovulate. Typically, this medication can lead to twins in about 9% of cases, and in this instance, the second pregnancy had a rare type of twin pregnancy called heterotopic pregnancy, where one embryo is in the uterus and the other is in a different location. It is important for doctors to inform patients about the chances of having multiple pregnancies and the rare possibility of this specific type of pregnancy before starting treatment. Who this helps: This helps patients undergoing fertility treatments.

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This research paper examined the relationship between endometriosis, a painful condition affecting 10% to 12% of women of reproductive age, and various cancers, particularly ovarian cancer. The review found that endometriosis could contribute to the development of gynecological cancers through shared risk factors and biological pathways, although more studies are needed to fully understand the connection. Understanding this relationship is important because it could lead to better diagnosis and treatment for women suffering from both conditions. Who this helps: This helps patients with endometriosis and their doctors in managing their health and reducing cancer risk.

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This study looked at how high sugar levels in diabetes affect kidney cells, leading to damage and loss of function. Researchers found that when rats' kidney cells were exposed to high glucose, there was more cell growth and damage due to increased levels of certain substances in the body. Specifically, they identified that the levels of 20-HETE and EETs, which are related to kidney injury, were altered, impacting a key pathway involved in kidney disease. Who this helps: This research helps patients with diabetes by identifying new mechanisms that contribute to kidney problems.

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This study looked at how often urinary retention happens after laparoscopic surgery for severe endometriosis and if there’s a link to nerve damage during the procedure. Out of 221 patients, 10 (or 4.6%) experienced urinary retention, but researchers found no difference in nerve damage between those who had this problem and those who didn’t. They discovered that older patients (average age of 40.3 years) were more likely to have ongoing issues, highlighting the need to balance effective surgery with protecting function in older patients. Who this helps: This helps patients undergoing surgery for endometriosis, especially older patients.

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This study looks at a surgical procedure called complete para-aortic lymphadenectomy, which is used in treating certain female cancers. The researchers created a new classification system for this surgery and documented various blood vessel abnormalities that can occur in this region. Understanding these abnormalities is crucial for ensuring that the surgery is done correctly and completely, ultimately improving patient outcomes. Who this helps: This helps doctors and surgeons performing gynecological cancer surgeries.

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This study looked at two women who had surgery through the vagina to remove their gallbladders after having weight loss surgery using the same approach. Both women, aged 57 and 32, had successful surgeries with no complications, and they resumed sexual activity about 5 weeks later with no issues. This is important because it shows that repeated transvaginal surgery can be done safely, which may lead to fewer complications like scar tissue in the future. Who this helps: This benefits patients who need multiple surgeries, especially those with a history of weight loss surgery.

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This study looked at how effective barcode scanning could be for tracking vaccines in clinics during flu seasons. It compared three methods: scanning barcodes, using dropdown menus, and recording on paper. The results showed that scanning took about 4.3 seconds per vial, which is longer than the other methods (0.5 seconds for dropdown menus and 1.7 for paper), but users were largely satisfied with the accuracy and safety improvements that scanning offered. Who this helps: This benefits clinic staff and patients by ensuring more accurate vaccine records and safer immunization processes.

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This research focused on the effectiveness of laparoscopic surgery for patients with severe ureteric endometriosis, which can cause kidney issues. Out of 13 patients studied, all had improvement in their pain, and major complications occurred in only 23% of cases, highlighting that this surgical approach is safe and effective for treating this condition. Proper diagnosis using imaging is crucial, as ureteric issues can often be unnoticed. Who this helps: This benefits patients suffering from severe endometriosis and healthcare providers treating these conditions.

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This study looked at a method to surgically remove a vaginal septum in a 12-year-old girl with a specific condition that caused a blockage in her vagina. After the procedure, any pain and menstrual problems were completely resolved, and follow-up checks showed no complications or return of the septum. This is important because it shows that the procedure is safe and effective, allowing for better health outcomes while keeping the patient’s virginity intact. Who this helps: This benefits young patients with similar conditions and their doctors.

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This study looked at how often doctors prescribed acid-reducing medications to patients in a hospital in Beirut and whether those prescriptions were necessary. Out of 153 patients, 130 (85%) were given these medications, but only 11 (8.5%) had a clear medical reason for needing them. This is important because too many patients are receiving these medications without need, which can lead to higher medical costs and possible side effects. Who this helps: This helps patients by reducing unnecessary treatments and their potential risks.

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This study looked at a case where a small bowel obstruction happened after a specific type of surgery to support pelvic organs. The researchers found that when a mesh used in the procedure isn’t completely covered by the tissue layer (peritoneum), it can lead to serious complications, like bowel herniation. They emphasized that covering the mesh properly is crucial to prevent these problems and that doctors should act quickly if patients show sudden abdominal pain after the surgery. Who this helps: This helps patients who have undergone laparoscopic sacrocervicopexy surgery.

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This study looked at urinary tract endometriosis (UTE) in 221 patients who had severe endometriosis and needed surgery. Researchers found that 19.5% of these patients had UTE, which can cause serious kidney issues, yet many may not realize they have it due to a lack of clear symptoms. The study highlights that while laparoscopic surgery to treat UTE is safe and effective, better pre-surgery detection methods are needed. Who this helps: This helps patients with endometriosis and their doctors.