DR. JAMES H. ROGERS JR., MD

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Researchers studied a type of inherited vision loss called autosomal dominant optic atrophy (ADOA) using rhesus macaques with a specific genetic mutation. They found that these macaques showed significant signs of vision impairment, including thinning of the nerve fibers in the eye and loss of important retinal cells, which mirrors the symptoms seen in humans with ADOA. This research is important because it helps us understand how ADOA develops and indicates that treatments tested in these macaques might also work for people with the condition. Who this helps: This helps patients with ADOA and their doctors seeking better treatments.

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This study looked at how often patients with specific types of lung cancer (EGFR, ALK, or ROS1-positive non-small cell lung cancer) get rebiopsied to understand their disease and adjust their treatment. Researchers found that among patients whose cancer got worse, 56% had a rebiopsy, and this rate increased over time—from 51% before 2018 to 70% in 2022-2025. This matters because tracking these rebiopsy rates helps improve treatment strategies for better patient outcomes. Who this helps: Patients with EGFR, ALK, or ROS1-positive non-small cell lung cancer.

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This research paper examines ways to safely test herbal products (botanicals) for potential harm to development and reproduction. The study identified 18 different herbal extracts, some of which are known to be harmful (like locoweed and poison hemlock), while others (like Asian ginseng) are considered low-risk. By developing new testing methods that do not rely heavily on animal models, the goal is to better understand the safety of these herbal products, which are frequently used by consumers. Who this helps: This benefits patients and consumers who use herbal supplements, ensuring their safety.

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This study focused on a 27-year-old man who suffered a thigh bone fracture while on a humanitarian mission with the U.S. Navy. After waiting a month due to a lack of medical resources, he was successfully treated on the USNS Mercy ship, where surgeons repaired his femur and he was able to walk independently just 17 months later. This is important because it shows that with proper planning and coordination, effective surgical care can be provided even in challenging situations. Who this helps: This helps patients in need of urgent care during humanitarian missions.

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This study evaluated a new reporting system for analyzing soft tissue samples taken from musculoskeletal lesions. Researchers looked at 592 samples, and they found that the accuracy of diagnosing cancer varied by category: 100% for malignant cases, 70% for uncertain cases, and 29% for nondiagnostic cases, among others. The findings demonstrate that using a standardized system can significantly enhance how doctors manage these conditions and diagnose patients. Who this helps: This helps patients with musculoskeletal issues by improving diagnosis and treatment plans.

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This study looked at how starting medical marijuana affects driving performance in adults aged 50 and older with chronic pain. The researchers found that those using medical marijuana reacted more quickly in a driving simulation task compared to non-users, with the marijuana group averaging a reaction time of about 2.57 seconds versus 5.79 seconds for the control group. This matters because it provides initial insights into how medical marijuana might influence everyday activities, like driving, for older adults. Who this helps: This research benefits older adults considering medical marijuana for pain relief and their doctors.

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This research examined how easily teenagers and adults can get medical and forensic care after experiencing sexual assault. The study reviewed 21 articles and found that while some factors, like how approachable services are, were well-studied, others, like the financial costs, were mostly ignored. Understanding these access issues is crucial for improving support for survivors and ensuring they receive timely care. Who this helps: This benefits patients who have experienced sexual assault.

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This study looked at a new test for a protein called glycosylated fibronectin (GlyFn) to see if it could help diagnose pre-eclampsia in pregnant women who might have the condition. The researchers found that GlyFn levels below 400 micrograms per milliliter could accurately rule out pre-eclampsia with a very good negative predictive value of 95.2%, although it wasn't as specific as existing tests measuring placental growth factor (PlGF). This is important because it could help ensure pregnant women receive the right care sooner, especially as they enter later stages of pregnancy. Who this helps: Pregnant women at risk for pre-eclampsia and their healthcare providers.

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This study examined how rheumatologists and palliative care specialists view palliative care for patients with rheumatic diseases in the U.S. It found that a significant number of rheumatologists—71.6%—rarely discuss advance care planning with their patients, and 67.2% have not referred anyone to palliative care in the past year. Meanwhile, 75.6% of palliative care clinicians reported feeling less comfortable treating rheumatology patients, though many agreed that patients with rheumatic diseases could benefit from their services. Who this helps: This research benefits patients suffering from rheumatic diseases by highlighting the need for better palliative care support.

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This study looked at how involving belief assessment can affect how students analyze data in a visual analytics course. It found that students who used belief elicitation took a more focused approach to their analysis, while those who didn’t showed a wider range of findings. However, both groups performed equally well in solving a data challenge, showing that belief elicitation can be a useful tool depending on the goal of the analysis. Who this helps: This helps educators and students in data analysis courses.

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This study looked at a training program for pharmacy technicians at University Hospitals to see how many trainees completed the program and returned to work after one year. The results showed that 77.8% of trainees finished the program, with 93.2% of graduates still employed at graduation, and after a year, 68.3% of program graduates were still working, compared to 61.3% of those hired from outside. This is important because it shows that the training program effectively produces qualified candidates for pharmacy technician jobs, which helps meet staffing needs in healthcare. Who this helps: This benefits healthcare systems and patients by ensuring that skilled pharmacy technicians are available.

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This study looked at the evolutionary history of true lemurs, a diverse group of primates from Madagascar, by analyzing their DNA. The researchers found that these lemurs have hybridized, or mixed genetically, among different species, which helps explain surprising differences in their genetic history. This research is important because it enhances our understanding of how these species evolved and lays the groundwork for future studies on their genetics. Who this helps: This helps scientists and researchers studying lemurs and their conservation.

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This study looked at why Black patients with systemic lupus erythematosus (SLE) are more likely to skip their medications compared to White patients. Among the 123 participants, only 44% of Black patients stuck to their medication plan, compared to 64% of White patients. Black patients expressed more worries about medication risks and questioned the need for their SLE medications, which may be linked to mistrust in medical treatment. Who this helps: This research helps doctors better understand and support Black patients with SLE to improve their medication adherence.

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This study looked at how to improve safety in hospitals by developing a program that allows families to report safety concerns more easily. Before the program, hospitals received an average of 0.4 safety reports per month from families, but after implementing the program, that number increased dramatically to 4.4 reports per month. This is important because it shows that when hospitals encourage input from families, they can better identify and address safety issues, ultimately leading to improved patient care. Who this helps: This helps patients and their families by giving them a voice in hospital safety.

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This study looked at burnout among leaders, highlighting that nearly 60% of them feel "used up" at the end of the workday. It found that when leaders experience burnout, it can negatively affect their teams and the organization as a whole, making it crucial for leaders to prioritize their own well-being. Addressing leadership burnout helps create a healthier work environment, ultimately benefiting everyone in the organization. Who this helps: This helps healthcare leaders and their teams.

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Researchers studied how human chromosomes differ from those of our closest relatives, like chimpanzees, specifically focusing on a unique event where two chromosomes fused together. They found important details about where this fusion happened and how it relates to other DNA sequences in great apes. Understanding this fusion is crucial because it helps explain some of the evolutionary changes that make humans unique. Who this helps: This helps scientists and researchers studying human evolution and genetics.

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This study examines advancements in mechanical circulatory support devices, particularly how they have improved to become smaller, more efficient, and safer for patients. Researchers found that the latest left ventricular assist devices have lower risks of complications and higher survival rates compared to older models. These innovations are important because they may provide better treatment options for patients with severe heart problems, improving their quality of life and longevity. Who this helps: Patients with severe heart conditions.

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This study looked at how to better analyze the relationship between drug doses and their effects on patients, using a structured method called the estimand framework. The researchers found that using this framework allows for more accurate estimates of how drugs perform, specifically noting that their pooled dose-exposure-response analysis gave better results compared to other methods, with reduced error rates. This is important because it helps ensure that the right drug doses are chosen, improving the safety and effectiveness of treatments. Who this helps: Patients and doctors involved in drug development and treatment decisions.

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This study looked at a new way to give high-dose radiation therapy to patients with advanced lung cancer. Researchers tested a treatment plan that involves 30 Gray of radiation delivered over just six sessions instead of the traditional longer schedule. They found it to be safe and effective, which is important because it could help patients spend less time in treatment while still receiving effective care. Who this helps: This benefits patients with advanced lung cancer who need radiation therapy.

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This research studied the effectiveness of a mobile sexual health education program called Next4You for adolescents in or transitioning from foster care. It involved 500 youth aged 16-19 in California, who either received the Next4You program or general health materials. The goal is to reduce risky sexual behaviors and improve knowledge about healthy relationships, and if successful, this could offer a valuable resource to help foster youth make safer choices regarding their sexual health. Who this helps: This benefits foster youth who need targeted support in sexual health education.

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This research developed a new method for adding specific isotopes to histidine in proteins produced in the bacteria E. coli. By testing various amounts of histidine, the study found that using 32 mg of histidine per liter of culture achieved over 98% labeling accuracy, which means the labels were successfully attached without interference. This method is important because it helps scientists better understand protein structure and function, which is crucial for processes like drug development and disease treatment. Who this helps: This benefits researchers and scientists working on protein-related studies.

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This study looked at how early skills and learning environments affect the executive function of Australian Aboriginal and Torres Strait Islander children as they grow. It involved 473 children and found that those with better preschool skills in visual motor tasks (a measure of .15) and self-regulation in early classrooms (a measure of .18) were more likely to develop stronger executive function in their teenage years. This research is important because it highlights the need for supportive home environments and accessible early learning services, especially in remote areas, to improve outcomes for these children. Who this helps: This helps children, families, and educators in Aboriginal and Torres Strait Islander communities.

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This study looked at how a specific treatment for preventing blood clots (thromboprophylaxis) impacts long-term survival in cancer patients with high risks for clots, particularly those with lung or gastrointestinal cancers. Patients identified as high-risk were given enoxaparin, a blood thinner, and those who received this treatment had a significant improvement in survival rates at 6 and 12 months compared to those who did not; however, by 36 months, the differences in survival rates became less notable. These findings point to the importance of using simple blood test results to help identify which cancer patients might benefit the most from receiving blood clot prevention treatments. Who this helps: This helps cancer patients at high risk for blood clots and their doctors.

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This study looked at how satisfied patients were with a new blood thinner, called apixaban, compared to the older option, low molecular weight heparin, for preventing blood clots after surgery for gynecologic cancers. Out of 50 patients surveyed, those on apixaban reported feeling better about taking their medication, had fewer concerns about the cost, and needed less assistance with their treatment. Importantly, none of the patients developed blood clots after surgery, and only one had a major bleed. Who this helps: This helps patients undergoing surgery for gynecologic cancers.

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This research paper discusses new devices that can be placed inside the body to diagnose and treat various health conditions. The authors highlight how these devices are designed for specific organs and can both monitor health and deliver therapy, offering new options compared to older treatments. They emphasize the potential of combining gene therapy with light stimulation to enhance these systems, and they address challenges and future directions for getting these innovations into hospitals. Who this helps: This research benefits patients with chronic diseases by providing them with more effective treatment options.

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This study examined how well individuals at high risk for psychosis adjusted to social and academic challenges before showing early signs of the illness. Researchers found that poor social and academic adjustment before symptoms appeared was linked to worse negative symptoms and cognitive problems, with significant correlations (for example, a strong link of 0.27 for academic issues and cognitive impairment). This is important because understanding these relationships can help identify at-risk youth earlier and support their needs before they develop more serious symptoms. Who this helps: This information benefits patients at high risk for psychosis and their healthcare providers.

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This study looked at how mutations occur in the gray short-tailed opossum, a small marsupial that matures quickly and reproduces before six months of age. Researchers found that these opossums have one of the lowest mutation rates in mammals, at about 0.25 mutations per billion base pairs per generation. Additionally, two-thirds of mutations came from the male parent, indicating a male bias similar to older species, but not entirely explained by how often males reproduce after puberty. This research helps us understand how age and sex impact genetic mutations, which is important for studying evolution and genetic diseases. Who this helps: This helps researchers studying genetics and evolution.

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This study examined six cases of a viral illness called borealpox in Alaska from 2020 to 2023. Researchers found that five patients showed similar symptoms like skin lesions and swollen lymph nodes, and one patient with a weakened immune system became seriously ill and died, despite treatment. The evidence suggests that the virus comes from small mammals, not from other people, which highlights the importance of understanding how animal viruses can affect human health. Who this helps: This information is useful for patients, especially those with weakened immune systems, and healthcare providers in Alaska.

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This paper focuses on soft wearable sensors, which are flexible devices that fit comfortably on the skin. Unlike traditional devices that can be stiff and uncomfortable, these soft sensors provide better monitoring of health by being more comfortable and able to stay in place during daily activities. As a result, they offer more accurate health data and can improve personalized healthcare options. Who this helps: Patients seeking more comfortable and effective health monitoring solutions.

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This study looked at the global campaign against female genital mutilation (FGM) and found that it can cause harm instead of helping. It reported that the anti-FGM message often ignores the diverse cultural practices and experiences of different communities, leading to negative effects like distrust in medical settings and racial profiling of migrant families. This is important because it shows that well-intentioned efforts can backfire, especially when they don't take into account the complexities of culture. Who this helps: This helps communities affected by FGM and healthcare providers by promoting a more respectful and informed approach.

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This study looked at a new imaging technique that uses a special type of magnetic resonance imaging to find areas in the brain that produce high levels of lactate, which is linked to epilepsy. The researchers found that this method accurately identified elevated lactate in models of epilepsy, suggesting it could be useful for pinpointing problem areas in the brains of people with epilepsy before surgery. This matters because better identification of these areas can lead to improved outcomes for patients who undergo surgery for epilepsy. Who this helps: This helps patients with epilepsy considering surgery to control their seizures.

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This study looked at the outcomes for patients with extensive-stage small cell lung cancer who received a second treatment after their first treatment with chemoimmunotherapy. Among 111 participants, only 22% responded to the second treatment, with an average survival of 5.8 months after starting the second-line therapy. These findings highlight that even after initial immunotherapy, options for further treatment are not very effective, indicating a need for better treatments for these patients. Who this helps: Patients with extensive-stage small cell lung cancer.

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This study looked at the effects of ADHD medications during pregnancy to help determine if mothers should continue their treatment or stop. The review found that in many cases, continuing ADHD medications did not significantly harm mothers or their babies; specifically, seven of the twelve studies indicated no serious negative effects. However, there was some evidence linking certain medications, like modafinil, to a higher risk of birth defects, while stopping ADHD medications could also raise the risk of complications like miscarriage. Who this helps: This information is valuable for pregnant women with ADHD and their healthcare providers.

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This study focused on how analyzing speech, facial expressions, and voice can help predict early signs of psychosis, a serious mental health condition. The researchers found that individuals at high risk for psychosis used more complex sentences but fewer descriptive words compared to those without such risk. Specifically, those at clinical high risk produced more referential language but had lower counts of adjectives and nouns. This research matters because it offers a new way to detect psychosis earlier, using everyday speech patterns as reliable indicators for early intervention. Who this helps: This helps patients at risk for psychosis and their healthcare providers by improving early detection methods.

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The European Resuscitation Council has released updated First Aid Guidelines for 2025, which detail how to handle various medical emergencies, such as choking, asthma attacks, and severe allergic reactions. They provide specific recommendations for first aid providers on essential skills like using a pulse oximeter, placing someone in the recovery position, and addressing life-threatening situations, including severe bleeding and cardiac arrest. These guidelines are important because they help ensure that first responders are prepared to save lives and provide the best possible care during emergencies. Who this helps: This benefits patients facing medical emergencies and the doctors and first responders treating them.

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The 2025 European Resuscitation Council (ERC) Guidelines provide updated recommendations for performing resuscitation in Europe, based on thorough scientific research. These guidelines cover a wide range of topics, including how to respond to cardiac arrest, both for adults and children, as well as specialized care scenarios and ethics in resuscitation. These updated rules are important because they help ensure that both healthcare workers and laypeople use the best practices to save lives in emergencies. Who this helps: This benefits patients experiencing cardiac arrest and the healthcare professionals involved in their care.

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This study outlines the new 2025 guidelines for basic life support (BLS) for adults, detailing how to recognize cardiac arrest, alert emergency services, and perform lifesaving techniques like chest compressions and using an automated external defibrillator (AED). The guidelines emphasize the importance of high-quality CPR and effective use of technology to improve outcomes during cardiac emergencies. Following these updated recommendations can significantly increase the survival chances of individuals in cardiac arrest. Who this helps: This helps patients experiencing cardiac arrest and those who assist in emergency situations.

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This study looked at how a treatment called oral immunotherapy (OIT) for cashew allergies affects the immune system. Out of 40 people with cashew allergies, 65% were able to tolerate a dose of 2043 mg of cashew after a year of treatment, and many showed signs that their immune response had weakened against the allergen. This matters because it shows that OIT can help people with cashew allergies reduce their allergic reactions and potentially improve their quality of life. Who this helps: This helps patients with cashew allergies.

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This study looked at 220 people with chronic heel pain over 12 months to see how mental and physical factors affect recovery. It found that those who were more likely to worry about their pain (pain catastrophizing) and had more nerve-related pain symptoms (neuropathic symptoms) had worse pain recovery. Specifically, for every increase in pain catastrophizing and neuropathic pain scores, participants experienced a decrease in pain recovery. Who this helps: This research benefits patients with chronic plantar heel pain by highlighting the importance of addressing both physical and mental aspects of their condition.

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This study looked at how to better measure pain in infants in the neonatal intensive care unit (NICU) using continuous monitoring with wireless sensors. Researchers found that two new tools, the Clinical Sensor Pain Scale (CSPS) and the Automated Sensor Pain Scale (ASPS), provided reliable pain assessments that matched well with traditional assessments in a group of 32 infants. Both tools showed a median pain score of 3, indicating they work effectively in diagnosing pain, which is crucial for improving pain management in vulnerable infants. Who this helps: This benefits infants in the NICU by providing better pain assessment and management.

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This study looked at how engineered T cells, known as CAR T cells, exert tiny forces when they interact with cancer cells. Researchers found that these CAR T cells can generate forces between 8 and 19 piconewtons (a unit of force) when they bind to cancer targets. This information is important because it could help improve CAR T cell therapies by identifying which T cells may work better against cancer, allowing for more personalized and effective treatments. Who this helps: This helps patients undergoing CAR T cell therapy by potentially leading to better treatment outcomes.

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Researchers studied a 68-year-old woman who experienced ongoing visual distortion after cataract surgery, despite medical imaging showing that her eye appeared to recover. They found that using advanced imaging technology revealed significant damage to the light-sensitive cells in her eye that wasn't visible with standard imaging methods. This finding is important because it highlights that even when patients seem to recover, there could still be hidden damage affecting their vision. Who this helps: This helps patients who experience unexplained vision problems after eye surgery.

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This study looked at how teachers and students in an Australian high school used research on self-regulated learning (SRL) after participating in a special training program. The findings showed that when teachers received ongoing support from researchers and worked closely with school leadership, they were more likely to implement SRL strategies in the classroom. This is important because teaching students to manage their own learning can improve their academic performance and engagement. Who this helps: This benefits students and teachers by enhancing learning strategies in the classroom.

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This study focused on a new tool called MosaicSim, designed to help detect genetic mutations in specific cells known as mosaic variants (MVs), which are important in various diseases. The researchers simulated 1,000 genetic changes and found that using coverage levels between 150 and 445 times the standard amount could accurately identify these variants, with a true-positive rate of about 50% to 55%, and no false positives. This matters because it improves how we can analyze complex genetic information and potentially leads to better understanding and treatment of diseases caused by these mutations. Who this helps: This helps patients and doctors by providing better tools for identifying critical genetic changes in diseases.

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This study examined how factors like sex, age, and body mass index (BMI) affect the quality of focused cardiac ultrasounds (FOCUS) in adults. Researchers looked at 1,200 patients and found that while overall ultrasound quality did not differ between men and women, the images of a key view were significantly poorer in women, with a failure to capture this view occurring more than in men (who had over 60% higher odds of getting a clear view). This is important because it highlights potential gaps in care for women and older individuals, who may not receive the best diagnostic images, affecting their treatment. Who this helps: This helps patients, particularly women and older adults, by drawing attention to disparities in cardiac care.