Dr. Dettling's primary research interests include the mechanisms that affect hearing and how individuals make decisions under pressure. He investigates how specific proteins in our inner ear contribute to hearing capabilities and how genetic factors can influence these processes, especially regarding hearing loss. He also explores cognitive aspects affecting how people approach tasks, such as decision-making when carrying groceries or other items while trying to remember certain information. His work is vital for patients facing hearing challenges and for those seeking to understand better how memory interacts with task execution.
Key findings
In his grocery-carrying study, participants were found to carry more items in their first trips, particularly when needing to remember a set of numbers, indicating a strong preference for completing tasks quickly.
Research on thyroid hormone receptors revealed that certain mutants in mice displayed normal hearing but delayed cellular processes, shedding light on factors contributing to deafness.
Findings showed that mice without AMPK struggled to recover from noise-induced hearing damage, suggesting that AMPK plays a critical role in hearing protection.
A study detailing the effects of vardenafil treatment showed it almost completely prevented hearing loss in mice lacking a protective gene.
In shoulder studies, swimmers had an average shoulder translation of 12.4 mm, compared to 9.6 mm in soccer players, highlighting differences in shoulder stability among athletes.
Frequently asked questions
Does Dr. Dettling study hearing issues?
Yes, Dr. Dettling researches the biological factors affecting hearing and how they relate to conditions like deafness and hearing loss.
What treatments has Dr. Dettling researched for hearing loss?
He has investigated the protective effects of medications like vardenafil which show promise for preventing noise-induced hearing loss.
Is Dr. Dettling's work relevant to patients with decision-making problems?
Yes, his studies on how cognitive factors influence decision-making can help understand behaviors related to task completion under pressure.
What specific conditions does Dr. Dettling's research help?
His research provides insights into hearing loss, cognitive performance during task execution, and motor planning issues.
How does Dr. Dettling's work assist athletes?
His research on shoulder stability helps inform training and rehabilitation practices for athletes, particularly to prevent injuries.
Publications in plain English
Carrying groceries: More items in early trips than in later trips or the reverse? Implications for pre-crastination.
2023
Psychological research
Rosenbaum DA, Dettling J
Plain English This study looked at how many bags of groceries people carry during their trips to the car, focusing on whether they tend to carry more bags early on or later in the process. Researchers found that participants carried more items in their initial trips, particularly when they had to remember a set of numbers afterward, indicating that people tend to prefer completing tasks sooner rather than later. This matters because it helps us understand how people make decisions under pressure or memory challenges.
Who this helps: This helps researchers and psychologists studying decision-making behaviors.
Visuomotor priming of action preparation and motor programming is similar in visually guided and memory-guided actions.
2016
Neuropsychologia
Seegelke C, Güldenpenning I, Dettling J, Schack T
Plain English This study looked at how our brain helps us prepare and execute hand movements when reaching for objects, even when we can't see them. Researchers found that when participants saw a relevant object (like a handshape) before being prompted to grasp something, they reacted faster compared to when they saw an irrelevant object. The speed of movement initiation was slower when no prime was shown at all, but how they moved was not impacted by this lack of prime. Overall, the findings show that how we prepare for movements is similar whether we rely on visual feedback or remember how to act, suggesting our brains use the same mental images for both types of actions.
Who this helps: This helps patients with motor planning issues and neurologists working on rehabilitation strategies.
Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells.
2014
Molecular and cellular endocrinology
Dettling J, Franz C, Zimmermann U, Lee SC, Bress A +7 more
Plain English This study examined the roles of two thyroid hormone receptors, TRα and TRβ, in the hair cells of the inner ear, which are crucial for hearing. Researchers found that TRβ is linked to deafness from outside the hair cells, while TRα and TRβ have opposing effects on how these hair cells function. Specifically, TRβ mutants had normal hearing but delayed certain cellular processes, while TRα mutants maintained certain functions but showed increased response amplitudes to sound.
Who this helps: This helps patients with hearing issues and their doctors by providing insights into the genetic factors affecting hearing.
Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell.
Plain English This study looked at how a protein called prestin in ear cells affects hearing by producing mechanical force. Researchers found that when the distribution of prestin doesn't develop properly, as seen in thyroid issues, the hearing ability is significantly weakened—up to 70% reduced force. This is important because it reveals how essential the correct positioning of prestin is for good hearing, which could help improve treatments for hearing loss.
Who this helps: This helps patients with hearing loss, particularly those with thyroid-related conditions.
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.
2012
Nature medicine
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A +18 more
Plain English This study investigated how a specific signaling pathway in the inner ear affects hearing loss caused by loud noise. Researchers found that mice lacking a certain gene (Prkg1) were more susceptible to noise-induced hearing loss and didn’t recover as well as normal mice. When they treated mice and rats with a drug called vardenafil, it almost completely prevented hearing loss, showing that this signaling pathway offers protection to the cells responsible for hearing.
Who this helps: This helps patients at risk of noise-induced hearing loss.
AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation.
2012
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T +7 more
Plain English This study looked at a protein called AMPK and its role in regulating a specific type of potassium channel (BK channels) in the inner ear. Researchers found that mice without AMPK had fewer BK channels and struggled to recover from hearing damage caused by loud sounds, while normal mice recovered well. Understanding how AMPK works could lead to better strategies for protecting hearing after exposure to loud noises.
Who this helps: This helps patients at risk of hearing loss, especially in noisy environments.
Quantitative assessment of glenohumeral translation.
2002
Clinical orthopaedics and related research
Tibone JE, Lee TQ, Csintalan RP, Dettling J, McMahon PJ
Plain English This study looked at how much the shoulder joint can move in female athletes, specifically comparing soccer players and swimmers. It found that swimmers had more movement in their shoulders, with an average of 12.4 mm in the dominant arm, while soccer players averaged 9.6 mm. Understanding these differences is important because it helps assess shoulder stability and guide training or rehabilitation practices to prevent injuries.
Who this helps: This helps doctors and physical therapists working with athletes.
Age related biomechanical properties of the glenoid-anterior band of the inferior glenohumeral ligament-humerus complex.
1999
Clinical biomechanics (Bristol, Avon)
Lee TQ, Dettling J, Sandusky MD, McMahon PJ
Plain English This study looked at how the shoulder ligament complex behaves differently in younger and older individuals. Researchers found that the ligament in younger people was stronger and more resistant to injury, with older individuals' ligaments showing only 61% of the strength of younger ones when tested. This is important because younger people often face more severe shoulder instability, which may require different repair methods than those needed for older adults.
Who this helps: This information benefits orthopedic surgeons and patients dealing with shoulder issues.
The anterior band of the inferior glenohumeral ligament. Assessment of its permanent deformation and the anatomy of its glenoid attachment.
1999
The Journal of bone and joint surgery. British volume
McMahon PJ, Dettling J, Sandusky MD, Tibone JE, Lee TQ
Plain English This study looked at the mechanics and anatomy of a key ligament in the shoulder called the anterior band of the inferior glenohumeral ligament. Researchers tested how strong this ligament is when it pulls away from the shoulder joint and found that it can withstand a force of about 491 N before starting to fail. Understanding this ligament better is important because it helps doctors improve surgical treatments for shoulder instability, which affects many patients.
Who this helps: Patients with shoulder instability issues.
Nocturnal and circadian body temperatures of depressed outpatients during symptomatic and recovered states.
1994
Psychiatry research
Monk TH, Buysse DJ, Frank E, Kupfer DJ, Dettling J +1 more
Plain English This study looked at the body temperatures of 41 people with recurrent depression, both while they were experiencing symptoms and after they recovered. Researchers found that those who recovered solely through therapy had similar nighttime temperatures to healthy individuals, suggesting that their body temperature rhythms were normal again. However, for those who needed medication, there were some temperature differences, possibly linked to their treatments.
Who this helps: This research benefits patients with depression and their doctors by providing insights into body temperature patterns related to treatment options.