FRANK D. ELLIS, M.D.

GAINESVILLE, FL

Research Active
Orthopaedic Surgery NPI registered 21+ years 50 publications 1976 – 2025 NPI: 1417954082
LiverRatsCells, CulturedStrokeRecovery of FunctionDogsRadiotherapy DosageUpper ExtremityStroke RehabilitationActivities of Daily LivingDose-Response Relationship, RadiationAdenosineIn Vitro TechniquesRadiotherapyTelerehabilitation

Practice Location

4500 W NEWBERRY RD
GAINESVILLE, FL 32607-2245

Phone: (352) 336-6000

What does FRANK ELLIS research?

Dr. Ellis studies how cognitive decline, particularly in subjective cognitive decline (SCD), affects memory performance and can indicate early memory issues. He also explores mental health in displaced populations, emphasizing the role of resilience in improving psychological outcomes for individuals who have been forcibly uprooted from their homes. Additionally, he investigates innovative rehabilitation techniques for stroke survivors, including virtual rehabilitation systems to enhance recovery of upper limb function, and the effectiveness of exercise programs for children with conditions like scoliosis.

Key findings

  • Individuals with subjective cognitive decline scored lower on memory tests, with a performance difference of -0.19 compared to healthy individuals and +1.20 compared to those with mild cognitive impairment.
  • Higher resilience among forcibly displaced individuals was linked to a 15% reduction in post-traumatic stress symptoms, 34% in depression, and 19% in anxiety.
  • In a study of a virtual rehabilitation program for stroke survivors, 88% of participants completed the program, performing between 1,710 to 9,377 exercise repetitions over 12 weeks, with some showing improvement in arm movement speed and function.

Frequently asked questions

Does Dr. Ellis study memory issues?
Yes, he studies subjective cognitive decline and its impact on memory performance.
What treatments has Dr. Ellis researched for stroke recovery?
He has researched virtual rehabilitation systems designed to help stroke survivors recover upper limb function.
Is Dr. Ellis's work relevant to mental health programs?
Absolutely, especially for displaced individuals, as his findings highlight the importance of resilience in improving mental health outcomes.
What specific populations does Dr. Ellis focus on?
He focuses on various populations, including stroke survivors and forcibly displaced individuals.
Has Dr. Ellis researched effective programs for children with scoliosis?
Yes, he has examined an exercise program that significantly improves balance in children with adolescent idiopathic scoliosis.

Publications in plain English

Resilience and its association with mental health among forcibly displaced populations: A systematic review and meta-analyses.

2025

Journal of affective disorders

Lane R, Taylor H, Ellis F, Rushworth I, Chiu K

Plain English
This study looked at how resilience—the ability to bounce back from tough situations—connects to mental health in people who have been forcibly displaced, like refugees. Researchers analyzed 31 studies with a total of 6,656 participants and found that higher resilience is linked to fewer symptoms of post-traumatic stress (15% reduction), depression (34% reduction), anxiety (19% reduction), and psychological distress (29% reduction). This is important because it highlights that building resilience can help improve the mental health of displaced individuals, potentially guiding support programs. Who this helps: This helps patients, particularly those who have been displaced, as well as the organizations that support them.

PubMed

Low impact development sand filter media replacement: Costs and effect on pollutant removal efficiencies.

2025

Journal of environmental management

Ellis F, Johnson DW, Brown KE, Giacomoni MH, Kapoor V

Plain English
This study looked at how replacing the sand in stormwater filters affects their ability to remove pollutants in Texas, focusing on maintenance records from 2017 to 2022. The researchers found that replacing the top layer of sand didn't significantly change the filter's ability to remove suspended solids, but there was a drop in the removal of harmful substances like total coliforms and metals after maintenance. It costs an average of $18,462 to replace the sand, which is necessary to meet legal requirements. Who this helps: This benefits city planners and environmental managers who need to maintain effective stormwater systems.

PubMed

Memory Test Performance of People with Subjective Cognitive Decline Recruited From Different Settings: A Systematic Review and Meta-analysis.

2025

Neuropsychology review

Peterson KA, Leddy A, Ellis F, Meiser-Stedman R, Hornberger M

Plain English
This research looked at how well people who think they have memory problems (called subjective cognitive decline, or SCD) perform on memory tests compared to those who don't have such concerns. They found that people with SCD scored lower than those without SCD, but higher than individuals with mild cognitive impairment (MCI), showing a performance difference of -0.19 compared to healthy individuals and +1.20 compared to those with MCI. These findings matter because they suggest that SCD can indicate early memory issues that might require further evaluation, even though the differences in test scores were small and more research is needed to confirm their importance. Who this helps: This helps patients who are concerned about their memory and healthcare providers who assess cognitive health.

PubMed

Author Correction: Exceptional-point-based accelerometers with enhanced signal-to-noise ratio.

2023

Nature

Kononchuk R, Cai J, Ellis F, Thevamaran R, Kottos T

PubMed

Consideration-of-concept of EvolvRehab-Body for upper limb virtual rehabilitation at home for people late after stroke.

2022

Physiotherapy

Ellis F, Hancock N, Kennedy N, Clark A, Wells J +3 more

Plain English
This study looked at a home-based virtual rehabilitation system called EvolvRehab-Body, which is designed to help people recover the use of their upper limbs after a stroke. Out of 12 participants, 8 completed the program, showing a high adherence rate of 88% by performing between 1,710 to 9,377 exercise repetitions over 12 weeks. Some participants showed signs of improvement in their ability to use their arms, particularly in movement speed and function, but not in grip strength; these early results suggest that further research is needed to understand the therapy's potential benefits. Who this helps: This could benefit stroke survivors seeking effective rehabilitation options.

PubMed

Exceptional-point-based accelerometers with enhanced signal-to-noise ratio.

2022

Nature

Kononchuk R, Cai J, Ellis F, Thevamaran R, Kottos T

Plain English
This study looked at a new type of accelerometer that uses special points called "exceptional points" to improve how well it detects movement. The researchers found that their device had a threefold increase in its signal-to-noise ratio, making it much more effective at measuring accelerations compared to earlier designs. This improvement matters because it means that these sensors can provide more accurate data even in noisy environments. Who this helps: This helps engineers and researchers developing advanced sensors for various applications.

PubMed

Universal Mental Health Screening Practices in Midwestern Schools: A Window of Opportunity for School Psychologist Leadership and Role Expansion?

2022

Contemporary school psychology

Wood BJ, Ellis F

Plain English
This study looked at how many schools in the Midwest are using universal mental health screening to identify students who may have mental health issues. Most principals reported that their schools do not conduct these screenings due to challenges like lack of money and time, but many expressed interest in starting this practice if they received support. This matters because early identification can lead to timely help for students who need it, improving their overall mental health and school experience. Who this helps: This helps students who may be struggling with mental health issues and their teachers and school psychologists.

PubMed

Phthalate diversity in eggs and associations with oxidative stress in the European herring gull (Larus argentatus).

2021

Marine pollution bulletin

Allen SF, Ellis F, Mitchell C, Wang X, Boogert NJ +4 more

Plain English
This study examined how certain chemicals from plastics, known as phthalates, are found in the eggs of European herring gulls and how they relate to oxidative stress, which can harm the birds. Researchers found up to six different phthalates in the eggs, with higher levels of one specific phthalate linked to increased oxidative stress markers. This finding is important because it suggests that phthalates could negatively affect the health of gull chicks as they develop inside the eggs. Who this helps: This research helps wildlife conservationists and environmental health researchers understand the impact of pollution on bird populations.

PubMed

Effect of PSSE on postural sway in AIS using center of pressure.

2021

Studies in health technology and informatics

Selthafner M, Liu XC, Ellis F, Tassone C, Thometz J +1 more

Plain English
This study looked at how a specific exercise program for scoliosis (called PSSE) affects balance and posture in children with adolescent idiopathic scoliosis (AIS). After 12 weeks of doing these exercises, the children showed a 15% increase in forward-backward balance stability and a 25% decrease in side-to-side instability. Their pressure distribution on the feet also improved, indicating better balance, which is important for everyday activities. Who this helps: This helps children with scoliosis and their physical therapists.

PubMed

Neurophysiological changes accompanying reduction in upper limb motor impairments in response to exercise-based virtual rehabilitation after stroke: systematic review.

2021

Physiotherapy

Ellis F, Kennedy NC, Hancock NJ, Pomeroy VM

Plain English
This study looked at how exercise-based virtual reality training could help people recover movement in their arms after a stroke, and whether there were changes in brain function associated with this recovery. Out of 1387 studies screened, only four fit the criteria and showed that while some improvements in movement and brain function were noted, the research was inconsistent and didn't clearly show a direct link between the two. This is important because understanding these effects could help develop better rehabilitation strategies for stroke survivors. Who this helps: Patients recovering from stroke.

PubMed

Factors in Psychiatric Admissions: Before and During the Covid-19 Pandemic.

2021

Clinical neuropsychiatry

McCarron RH, Swann P, Artingstall J, Burn AM, Deakin J +14 more

Plain English
This study looked at why people were admitted to psychiatric hospitals before and during the COVID-19 pandemic in the UK. It found that during the early pandemic, factors like isolation and changes in daily routines became more important, with women and older adults being admitted more frequently. Specifically, the number of admissions related to COVID-19 was higher among single individuals and those with mood disorders. Who this helps: This research benefits mental health professionals and policymakers working to support vulnerable groups during challenging times.

PubMed

Robust Scattered Fields from Adiabatically Driven Targets around Exceptional Points.

2020

Physical review letters

Fernández-Alcázar LJ, Li H, Ellis F, Alú A, Kottos T

Plain English
This study looked at how certain targets that change over time affect the scattering of waves, which usually depends on the waves' properties. The researchers found that when these targets are manipulated for a sufficient amount of time, the scattered waves become stable and consistent, regardless of changes to the incoming waves. Specifically, this happened when the adjustment time was longer than a critical threshold; otherwise, the effects varied greatly. This discovery could be important for improving controls in technology, such as managing thermal and quantum effects. Who this helps: This helps engineers and scientists working with wave technologies.

PubMed

Preventing cardiovascular disease: Participant perspectives of the FAITH! Program.

2019

Journal of health psychology

Brewer LC, Morrison EJ, Balls-Berry JE, Dean P, Lackore K +7 more

Plain English
The study looked at how African-American participants in Minnesota felt about a program designed to prevent heart disease. Researchers found that participants were very positive about the program, noting it helped them learn healthy lifestyle habits and appreciate the quality of the materials and speakers involved. This matters because it shows that culturally tailored programs can be effective in reducing heart disease risks in underserved communities. Who this helps: Patients in African-American communities.

PubMed

Adiabatic Thermal Radiation Pumps for Thermal Photonics.

2019

Physical review letters

Li H, Fernández-Alcázar LJ, Ellis F, Shapiro B, Kottos T

Plain English
This research explored a new way to manage heat transfer between two objects that are at the same temperature, using a method called adiabatic pumping. The study found that by carefully designing the system to take advantage of wave interference, energy transfer can be made much more efficient, with the potential for significant performance improvements. In practical testing, they demonstrated this approach using a realistic electronic setup. Who this helps: This helps engineers and researchers developing more efficient thermal management systems.

PubMed

Quality of life in patients with primary and secondary lymphedema in the community.

2017

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Herberger K, Blome C, Heyer K, Ellis F, Münter KC +1 more

Plain English
This study looked at the quality of life for 301 people in Hamburg who have lymphedema, a condition that causes swelling. On average, patients reported a score of 2.4 out of 4 for how much lymphedema impacted their lives, with serious effects on their physical health, daily activities, and emotional well-being. Many patients also experienced significant pain, which is often neglected in their treatment, highlighting the need for better early diagnosis and care strategies. Who this helps: This helps patients with lymphedema and their healthcare providers.

PubMed

C-reactive protein does not impair insulin suppression of glucose release in primary hepatocytes.

2012

Nutrition, metabolism, and cardiovascular diseases : NMCD

Ellis F, Nivala A, Pfaffenbach KT, Gentile CL, Wang D +2 more

Plain English
Researchers studied how a protein called C-reactive protein (CRP) affects the liver's response to insulin when it comes to controlling blood sugar levels. They found that CRP does not increase the amount of glucose released by liver cells and it does not interfere with insulin's ability to reduce glucose release. This finding is important because it suggests that CRP does not impact insulin's effectiveness in managing blood sugar, which could be relevant for understanding diabetes treatment. Who this helps: Patients with diabetes.

PubMed

Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver.

2010

The Journal of nutrition

Pfaffenbach KT, Nivala AM, Reese L, Ellis F, Wang D +2 more

Plain English
This study looked at how a high-carbohydrate meal affects certain processes in rat livers and how a drug called rapamycin might influence that. It found that after eating, the liver kicks into gear to process fats and proteins, but when rapamycin was given, it stopped this process. Specifically, rapamycin blocked the activation of important pathways related to fat production and liver health. Who this helps: This research benefits patients dealing with liver issues related to diet and fat metabolism.

PubMed

RYR1 mutations in UK central core disease patients: more than just the C-terminal transmembrane region of the RYR1 gene.

2004

Journal of medical genetics

Shepherd S, Ellis F, Halsall J, Hopkins P, Robinson R

PubMed

The discovery and synthesis of highly potent, A2a receptor agonists.

2000

Bioorganic & medicinal chemistry letters

Keeling SE, Albinson FD, Ayres BE, Butchers PR, Chambers CL +10 more

Plain English
Researchers created and tested new compounds that interact with a specific receptor called A2a, which is important for immune system function. They found that certain compounds were very effective at activating this receptor in human immune cells, particularly those with specific chemical features. This discovery could lead to better treatments for conditions involving the immune system, such as inflammation or autoimmune diseases. Who this helps: Patients with immune-related conditions.

PubMed

Reconstruction of the flexor pulley. The effect of the tension and source of the graft in an in vitro dog model.

1998

The Journal of bone and joint surgery. American volume

Seiler JG, Uchiyama S, Ellis F, Amadio PC, Gelberman RH +1 more

Plain English
Researchers studied how different types of tendons and tension levels affect the reconstruction of flexor pulleys in dogs' paws. They found that using tendons from the flexor digitorum profundus (an intrasynovial source) produced significantly less friction for tendon movement compared to tendons from the peroneus longus (an extrasynovial source), indicating a smoother recovery and function. Specifically, the flexor digitorum profundus grafts generated less friction than the peroneus longus grafts at the same tension, making them potentially better choices for surgical repairs. Who this helps: This research helps surgeons in choosing the best tendon for reconstructive surgery in patients with similar tendon injuries.

PubMed

Suppression of non-esterified fatty acids and triacylglycerol in experimental animals by the adenosine analogue GR79236.

1993

Clinical science (London, England : 1979)

Strong P, Anderson R, Coates J, Ellis F, Evans B +4 more

Plain English
This study focused on a new drug called GR79236 and how it affects fat and sugar levels in the blood. Researchers found that administering GR79236 to fasted rats and dogs significantly lowered the amounts of non-esterified fatty acids and triglycerides in their blood, which are important indicators of fat metabolism. This matters because controlling these levels could help understand and treat conditions related to excessive fat breakdown in humans. Who this helps: This benefits patients with metabolic disorders, doctors managing these conditions, and researchers studying fat metabolism.

PubMed

Functional characterization of three adenosine receptor types.

1993

British journal of pharmacology

Gurden MF, Coates J, Ellis F, Evans B, Foster M +5 more

Plain English
This study examined three types of adenosine receptors in various tissues and cells from different animals and humans to better understand their characteristics. Researchers discovered specific differences in how these receptors respond to certain compounds, with A1 receptors showing a strong response to compounds like CPA and GR79236, while A2 receptors varied in their response depending on the tissue type. Knowing these differences is important for developing targeted therapies that can effectively manipulate these receptors for better treatments. Who this helps: This benefits researchers and doctors aiming to create better medications for heart disease and other conditions related to adenosine receptors.

PubMed

Mustard gas casualties.

1991

Lancet (London, England)

Rees J, Harper P, Ellis F, Mitchell D

PubMed

Double electron excitation in atomic Xe.

1991

Physical review. B, Condensed matter

Zhang K, Stern EA, Rehr JJ, Ellis F

PubMed

Brigit Hendrika Paula van der Werf-Messing.

1990

International journal of radiation oncology, biology, physics

Ellis F, Levendag P

PubMed

Think pink.

1990

Nursing times

Ellis F

PubMed

Ten-year results of a post-operative prospective trial: NSD and LQ correspondence.

1989

The British journal of radiology

Ellis F

PubMed

The active site of hemerythrin as determined by X-ray absorption fine structure.

1988

Biochemistry

Zhang K, Stern EA, Ellis F, Sanders-Loehr J, Shiemke AK

Plain English
This study focused on understanding the active site of a protein called hemerythrin, which is important for oxygen transport in some organisms. Researchers used a technique called X-ray absorption fine structure to analyze how the distances between iron atoms in hemerythrin change when it releases oxygen. They found that when oxygen is released, the distance between the iron atoms increases from 3.24 angstroms in the oxygen-bound form to 3.57 angstroms in the oxygen-free form, which helps confirm previous theories about how this protein works. Who this helps: This research benefits scientists studying oxygen transport in living organisms and could aid in developing treatments for related health issues.

PubMed

Growing points in radiotherapy since 1930. The 65th Mackenzie Davidson memorial lecture 1984.

1987

The British journal of radiology

Ellis F

PubMed

Is NSD-TDF useful to radiotherapy?

1986

International journal of radiation oncology, biology, physics

Ellis F

PubMed

Nonunique structure of metastable (GaSb)1-x(Ge2)x alloys.

1985

Physical review letters

Stern EA, Ellis F, Kim K, Romano L, Shah SI +1 more

PubMed

Is NSD-TDF useful to radiotherapy?

1985

International journal of radiation oncology, biology, physics

Ellis F

PubMed

An outbreak of influenza A in a nursing home, 1982.

1984

New York state journal of medicine

Budnick LD, Stricof RL, Ellis F

PubMed

RBE and clinical response in radiotherapy with neutron beams.

1984

The British journal of radiology

Ellis F, Weatherburn H

Plain English
This study looked at the effects of neutron beams used in radiotherapy for treating pelvic tumors. Researchers found that instead of applying a constant effectiveness (called RBE) value of 3 for all neutron doses, it would be better to use a variable RBE that ranges from 3 to 8, depending on the dose given. This matters because using the wrong RBE leads to patients receiving too much radiation, which can affect healthy tissues in the pelvis and possibly lead to more side effects. Who this helps: This helps patients undergoing neutron therapy for pelvic tumors.

PubMed

The treatment of malignant melanoma.

1984

The British journal of radiology

Ellis F

PubMed

Parenteral depot method for zinc administration.

1981

Pharmacology

Brewer GJ, Ellis F, Bjork L

Plain English
This study looked at a new way to administer zinc through injections using a specific oil solution in rats and monkeys. Researchers found that injecting zinc raised the levels of zinc in the blood, with higher doses leading to even greater increases; for every unit of zinc injected, the blood concentrations rose accordingly. This method could be better than existing ones for studying zinc in animals and may eventually be useful for treating people. Who this helps: Patients needing zinc supplementation.

PubMed

NSD and fractionation.

1980

The British journal of radiology

Ellis F

PubMed

SI units and dimensions of NSD.

1979

The British journal of radiology

Ellis F

PubMed

Presidential address. Surgery--too little, science--too much.

1978

Transactions of the Medical Society of London

Ellis F

PubMed

Vascular responses with cinnarizine to standard exercise in patients with intermittent claudication.

1977

Proceedings of the Royal Society of Medicine

Ellis F, Hyams DE

PubMed

Cerebral necrosis following radiotherapy of extracranial neoplasms.

1977

Annals of neurology

Rottenberg DA, Chernik NL, Deck MD, Ellis F, Posner JB

Plain English
This study looked at six patients who developed brain damage (cerebral necrosis) after receiving radiation treatment for tumors outside the brain. Symptoms of brain damage appeared 4 to 31 months later, and all patients showed signs of blood vessel damage in the brain. Out of the six, four had surgery to remove the damaged tissue, and two patients are still alive and healthy 25 to 30 months later. Who this helps: This research helps patients who may experience delayed brain damage after radiation therapy, as well as their doctors in understanding and managing these complications.

PubMed

Once a week treatments.

1977

International journal of radiation oncology, biology, physics

Ellis F, Goldson AL

PubMed

134Cs--a potential radionuclide for radiation therapy.

1977

The British journal of radiology

Rao DV, Ellis F, Mallams JT

PubMed

134Cs for the treatment of cervical cancer.

1977

The British journal of radiology

Ellis F, Rao DV, Mallams JT

PubMed

Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy.

1976

Clinical radiology

Malaker A, Ellis F, Paine CH

Plain English
This study looked at a new way to treat keloid scars, which are raised scars that can be bothersome. Researchers combined surgery to remove the scar with a special type of radiation treatment using iridium-192, delivering a dose of 2000 rad. Out of 30 patients treated, only six had their scars return after two years, which is fewer than with other methods, and no complications were reported. Who this helps: This benefits patients with keloid scars, particularly young people who want effective treatment without more serious side effects.

PubMed

Letter: Acceptable radiation treatment schedules to the kidney.

1976

The British journal of radiology

Ellis F

PubMed

Letter: NSD and experimental work with pigs.

1976

The British journal of radiology

Ellis F

PubMed

Relationship between log dose and log time in radiotherapy--the Strandqvist lines.

1976

The British journal of radiology

Ellis F

PubMed

Heat wave deaths and drugs affecting temperature regulation.

1976

British medical journal

Ellis F

PubMed

Carcinoma of the maxillary antrum.

1976

Proceedings of the Royal Society of Medicine

Barley VL, Ellis F, Paine CH

PubMed

Frequent Co-Authors

Tsampikos Kottos Rodion Kononchuk Jizhe Cai Ramathasan Thevamaran Lucas J Fernández-Alcázar Huanan Li M F Gurden J Coates B Evans I Kennedy

Physician data sourced from the NPPES NPI Registry . Publication data from PubMed . Plain-English summaries generated by AI. Not medical advice.