DR. DANA ROSS JANSSEN, M.D.

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This study looked at how skin tone affects the accuracy of a medical device called near-infrared spectroscopy (NIRS) in measuring oxygen levels in children under 21 undergoing heart procedures. Researchers found that the device was less accurate for children with darker skin, showing NIRS values that were about 12.8% lower for those with darker tones compared to those with lighter skin. This matters because inaccuracies in readings could lead to unequal care and worse health outcomes for children with darker skin. Who this helps: This benefits doctors and healthcare providers by highlighting the need for improved devices and guidelines to ensure all children receive appropriate care.

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This study looked at how different levels of interference fit (350 micrometers and 700 micrometers) affect the stability of cementless knee implants. The researchers found that while a higher interference fit led to slightly less movement and gaps between the implant and bone, these changes weren't significant. However, they observed a notable increase of 15.7% in bone deformation with the higher fit, which could potentially lead to more damage to the bone. Who this helps: This helps patients receiving knee implants, ensuring better outcomes and reduced risk of bone damage.

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This study looked at how accurately modeling the way implants fit into bones affects their stability in knee and ankle surgeries. Researchers found that without considering the press-fit method, previous studies may have seriously undervalued how stable the implants are, which is crucial for preventing them from failing over time. The key takeaway is that using the right modeling techniques can lead to better predictions of implant performance and improve patient outcomes. Who this helps: This benefits patients undergoing knee and ankle replacement surgeries.

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This study looked at how the shape and alignment of knee bones affect knee movement in healthy people. Researchers reviewed 29 studies and found that specific features of the thigh bone and shin bone significantly relate to knee motion during activities, while the kneecap's shape is less influential. Understanding these relationships is important for improving knee assessments and treatments, as they can enhance insights into normal knee function. Who this helps: This helps doctors and researchers examining knee health and function.

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This study looked at a device called the KneeReviver, which is designed to help younger patients (ages 45-65) with knee osteoarthritis by temporarily separating bones to relieve pressure on cartilage. Researchers found that using longer and thinner pins along with springs in the device increased the pressure on cartilage and reduced the initial gap between bones, which can lead to faster healing. Understanding these factors is important for improving future designs of the KneeReviver and tailoring treatments to individual patients. Who this helps: This helps patients with knee osteoarthritis seeking non-surgical treatment options.

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This study looked at a new type of knee replacement made entirely from a polymer called PEEK instead of metal. Researchers tested this prosthesis using X-rays, CT scans, and MRIs to see how well they could detect common complications like loosening and fractures. They found that while all three imaging methods could clearly show the implant and its issues, CT scans provided the most detailed images, and MRIs were best at spotting fluid problems around the implant. Who this helps: This research benefits patients receiving knee replacements and the doctors who care for them.

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This study focused on improving knee implant placement for patients undergoing total knee replacement surgery, which is often needed for advanced knee arthritis, but can leave some patients unhappy. Researchers used a computer model trained with data from eight patients to predict the best positions for knee implants, aiming to restore normal movement and reduce strain on ligaments. The results showed strong agreement between the predicted and actual outcomes, suggesting that this method could lead to better personalized surgical results. Who this helps: This helps patients undergoing knee replacement surgery.

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This study looked at how different factors affect the movement of knee implants in the bone when they are first placed. It found that including bone abrasion in the model increased the predicted movement of the implant, making it align closely with actual measurements taken from cadaver bones—showing a prediction of 53.0 micrometers compared to an experimental measurement of 53.1 micrometers. Understanding these factors is important for ensuring that knee implants stay securely in place over time, which can help reduce the need for further surgeries. Who this helps: This helps patients who receive knee implants, as well as the doctors who perform the surgeries.

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This study analyzed the movement behaviors of 1,132 laying hens using a special automated tracking system. Researchers found that the hens were mostly undetected due to various limitations, but still, they collected enough data to estimate genetic traits related to their behavior. The traits showed some genetic variation, with heritability estimates indicating that these behaviors can be passed down; for daily measurements, heritability was between 0.13 and 0.26, meaning there's a moderate genetic influence on how these behaviors are expressed. Who this helps: This research benefits poultry farmers and breeders looking to improve the welfare and efficiency of laying hens.

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This study looked at how the knees of healthy people and those with osteoarthritis move when bending and straightening, using special CT scans. The researchers found that healthy knees mostly pivot inward (58%) while osteoarthritis knees tend to have less defined pivot patterns, with nearly half (45%) showing no pivot at all. Additionally, the movement of the femoral condyle (the rounded end of the thigh bone) was more pronounced in osteoarthritis knees compared to healthy ones (6.2 mm vs. 3.7 mm), which could impact how knee replacements are aligned. Who this helps: This research benefits doctors and surgeons involved in knee replacement procedures.

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This study examined how different bone behaviors affect the stability of cementless knee implants. It found that when accounting for the bone's plastic behavior, the force needed to pull the implant out dropped significantly—from 31 kN to 6.3 kN, a decrease of about 79%. Understanding these factors is crucial for improving the design and effectiveness of knee implants to ensure they stay in place longer. Who this helps: This benefits patients receiving knee implants and the doctors who perform these surgeries.

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This study looked at how to attach a graft for reconstructing the lateral patellofemoral ligament (LPFL) in the knee to ensure it works properly and reduces complications. Researchers analyzed 104 knees and tested four different methods for placing the graft. They found that one method, which attaches the graft at the center of the lateral trochlear ridge, resulted in the smallest changes in length during knee motion (only 2.7 mm), which is important for stability and function. Who this helps: This benefits patients undergoing knee surgery for patellar instability.

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This study focused on a virus called the Tomato Leaf Curl New Delhi Virus-ES (ToLCNDV-ES), which affects plants like zucchini, melon, and cucumber. Researchers found a way to quickly and accurately detect this virus in plants using a laboratory technique called real-time quantitative PCR, which is more sensitive than previous methods. This matters because timely detection can help control the spread of the virus, preventing damage to crops and ensuring food security. Who this helps: This benefits farmers and agricultural workers who grow these affected crops.

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This study looked at two different ways to simulate how well a knee implant will stay fixed in place after surgery. Researchers tested the materials used in simulations against real bone samples and found that one model, called Isotropic Crushable Foam (ICF), was better at matching real bone behavior, showing an average movement of about 27 micrometers at the implant-bone interface. This is important because understanding how implants interact with bone can improve their design and help them last longer in patients. Who this helps: This benefits patients undergoing knee replacement surgery.

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This study looked at how human trabecular bone (the spongy bone inside our larger bones) behaves under stress over time, which is important for improving models that predict how well implants will hold in place without cement. Researchers found that when they tested bone samples from the femur and tibia, the average stress relaxation—how much the bone can deform when under pressure—was about 54.4%, with some samples relaxing as much as 81.6%. This research is crucial because it helps make models for orthopedic implants more accurate, which can lead to better outcomes for patients needing these devices. Who this helps: Patients receiving orthopedic implants.

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This study looked at how the fit between cementless knee implants and bone affects their stability, which is important for long-term success. Researchers found that a tighter fit (350 μm) can lead to more bending in the bone, which limits stability, while a looser fit (700 μm) allows more movement that can compromise the implant's grip. The research shows that just making the fit tighter might not always improve stability and stresses the need to consider real-life activities, like walking and squatting, for better assessments. Who this helps: This benefits patients getting knee implants and the doctors who perform the surgeries.

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This study looked at how the fit of knee implants affects their stability over time. Researchers found that when they included factors like how bone relaxes and wears down, the predictions for how well the knee implant would hold up became much more accurate. Specifically, omitting bone wear led to overestimating implant strain by up to 360%, while including it brought predictions closer to real-world measurements. Who this helps: This helps patients who receive knee implants by ensuring that the implants are more securely fixed and reduce the chances of needing future surgery.

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This study looked at the effectiveness of a new treatment for bladder pain syndrome in patients with specific bladder lesions. Researchers tested how this treatment, which involves using certain substances in the bladder, impacts patient pain levels compared to a placebo. They found that the treatment did not show a significant carry-over effect, which means that past treatments did not influence the results of the placebo phase; thus, the trial can proceed using fewer patients than typically required. Who this helps: This research benefits patients dealing with chronic bladder pain, offering hope for more effective treatments.

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This study looked at a device called KneeReviver, which is used to help younger patients with osteoarthritis in their knees by keeping the knee joint space open and relieving pressure on the cartilage. Researchers tested the device using five cadaver knees under different weights and found that it significantly reduced pressure and load on the cartilage, but it didn't fully maintain the joint space during regular activities like walking with crutches. This is important because while the device helps to relieve pressure, it may not fully protect the joint space as intended, which could impact patient outcomes. Who this helps: This research helps patients with knee osteoarthritis and their doctors understand the effectiveness of the KneeReviver device.

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This research focused on improving how doctors measure and understand the impact of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) on patients. The committee made 12 recommendations, highlighting the need for a specific patient-centered measurement tool, as the current methods are not fully effective. They suggest using the Genito Urinary Pain Index (GUPI) for clinical trials and recommend other tools like pain scales and diaries to track symptoms in the meantime. Who this helps: This helps patients suffering from Interstitial Cystitis/Bladder Pain Syndrome and the doctors treating them.

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This research paper examines how ideas about gender identity developed from the late 18th century to the late 19th century, focusing on historical concepts like "dynamic hermaphroditism" and "sexual inversion." It highlights that although early thinkers struggled to understand diverse gender expressions, scholars like Richard von Krafft-Ebing advanced the discussion significantly, exploring the relationship between a person's feelings about their gender and their physical body. Understanding these historical developments is crucial as it informs modern concepts of gender identity, contributing to better recognition of non-cisgender individuals today. Who this helps: This benefits patients who identify as non-cisgender by improving awareness and understanding of their experiences.

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This study looked at how knee movement changes before and after total knee replacement surgery using a special type of CT scan. The researchers found that after surgery, the kneecap showed more flexion and rotation, with specific changes measured (for example, an increase in medial proximal tip rotation by about 1.5 to 6 degrees). Understanding these changes matters because it could help improve surgical techniques and patient outcomes in the future. Who this helps: This helps patients undergoing knee surgery and their doctors.

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Researchers developed and tested a new screening tool called EHSAS to help identify older adults in rural India who need comprehensive geriatric assessment (CGA). The tool includes 11 questions and works well, with about 76% accuracy in identifying those who are frail, making it easy and reliable for community health workers to use. This is important because it can lead to better care for older adults who might otherwise not receive the help they need. Who this helps: Community health workers and older adults in rural areas.

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This study examined the structure of knee joints using 3D imaging to compare the symmetry between knees in individuals with and without a condition called trochlear dysplasia, which increases the risk of knee instability. Researchers analyzed CT scans from 187 people and found that both groups had high levels of symmetry in their knee bones, with only minor differences that are not likely to be clinically important. The findings highlight that even in cases of knee dysplasia, the general shape of the knee remains surprisingly similar from left to right, which can help doctors evaluate and plan treatments for knee conditions. Who this helps: This helps patients with knee issues, particularly those with dysplasia, by providing insights into their knee anatomy.

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This study looked at how bone loss around knee implants can affect their stability and longevity. Researchers created models to simulate what happens to the bone and the implant when someone walks or stumbles. They found that while regular walking did not cause issues, a stumble could lead to serious problems, particularly for patients with poor bone quality, where there was a significant risk of the implant sinking into the bone. Who this helps: This research helps patients with knee implants, especially those with weaker bones, by highlighting the importance of bone health for successful surgeries.

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This study looked at how the bladder lining, called the urothelial barrier, works in people with bladder pain syndrome (IC/BPS) using various laboratory models. Researchers found that certain treatments, like glycosaminoglycan replenishment therapy, can help protect and improve the bladder lining's function, which is often damaged in IC/BPS. Understanding these mechanisms is crucial because it can lead to better treatments for this painful condition that affects many people. Who this helps: This helps patients suffering from bladder pain syndrome.

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This study explored how the texture of coatings on bone implants affects their stability once placed in the body. Researchers tested different surface roughness levels and found that rougher coatings had a higher coefficient of friction, leading to greater stability, but also to more movement without actual sliding between the implant and bone—up to 35 micrometers. Understanding these interactions can help improve implant design, ensuring they integrate better with bone and perform more effectively. Who this helps: Patients receiving orthopedic implants.

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This study looked at how bovine trabecular bone behaves under pressure over time, focusing on its stress relaxation properties. Researchers found that most stress relief occurs quickly, with up to 53% happening in the first 10 minutes and a total of 69% after 24 hours. Understanding these characteristics will help improve models used for designing orthopedic implants, making them more reliable. Who this helps: This benefits orthopedic surgeons and their patients by improving implant design and patient outcomes.

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This study looked at how patient characteristics, like body weight and implant material, affect the stability of knee replacements made from either PEEK or titanium. Researchers found that PEEK implants moved more than titanium ones when patients walked or squatted, and heavier patients experienced even greater movement with both materials. This matters because less stability can lead to complications after surgery, a concern for doctors and patients choosing knee replacement options. Who this helps: This helps patients undergoing knee replacement surgery, especially those who are overweight.

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This study looked at a 31-year-old woman with a heart condition called transposition of the great arteries, who was suffering from a severe blockage in her blood flow. Instead of traditional treatments that were considered too risky, doctors used a new, less invasive method through a small incision under the breastbone, which was guided by advanced 3D modeling. This approach showed promise for reducing risk while effectively treating the obstruction. Who this helps: This benefits patients with complex heart conditions, particularly those needing treatment for pulmonary venous baffle obstructions.

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This study examined how well a new type of knee implant made from a material called PEEK stays in place compared to traditional cobalt-chrome implants, considering factors like a patient's weight. Researchers found that the PEEK implants showed more movement than the cobalt-chrome ones, especially in patients with higher body mass index (BMI). This is important because ensuring a stable fit for implants can lead to better long-term results for patients after knee surgery. Who this helps: Patients undergoing knee surgery, particularly those with metal sensitivities.

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The study focused on the link between forward head posture and cardiorespiratory fitness in people with psychotic disorders, comparing them to individuals with autism spectrum disorder and healthy individuals. It found that those with psychotic disorders have a significantly lower head and neck angle, which correlates with lower cardiorespiratory fitness scores; specifically, a 45% lower fitness level was noted in this group. Improving cardiorespiratory fitness is essential for better physical and mental health, particularly for individuals with psychotic disorders. Who this helps: This benefits patients with psychotic disorders.

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This study looked at how healthy knees move by scanning them with a special type of imaging called dynamic CT. Researchers examined 120 knees and found two different groups with distinct movement patterns: one group had 53 knees with more internal rotation, while the other group had 67 knees with less. Understanding these variations in healthy knee movement is important for future research, particularly when comparing healthy knees to those with problems. Who this helps: This helps doctors and researchers working on knee health.

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This study explored how the knee moves in people who are healthy by using a type of advanced imaging called dynamic CT scans on 100 volunteers. Researchers found specific movement details, such as that the knee experiences a median internal rotation of 4 degrees and that the patella (kneecap) flexes at a median rate of 65% of overall knee flexion, providing an important benchmark for healthy knee movement. This information is crucial for diagnosing knee problems and evaluating treatment effectiveness in patients with knee disorders. Who this helps: This helps patients with knee issues and doctors who diagnose and treat those conditions.

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This study looked at the safety and outcomes for small infants weighing less than 2.5 kg who underwent a procedure to close a heart vessel called the patent ductus arteriosus (PDA) using a device. The researchers found that this procedure was highly successful, with a 98.7% success rate and only a 1.7% rate of serious complications, which included one death. These results are important because they show that the procedure can be safely performed on very small infants in various hospitals, giving them a better chance at a healthy life. Who this helps: This helps infants with heart conditions and their doctors.

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This study looked at the effectiveness of a therapy called glycosaminoglycan (GAG) for treating bladder pain syndrome/interstitial cystitis (BPS/IC), particularly in patients with a specific type of lesion. Researchers tested a treatment that combines hyaluronic acid and chondroitin sulfate on 80 patients, comparing it to a placebo. They measured results based on the maximum bladder pain over a few days, using a scale from 0 to 10, to provide strong evidence on whether this therapy should be recommended and covered by insurance. Who this helps: This helps patients suffering from bladder pain syndrome/interstitial cystitis.

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Researchers studied the urinary microbiome of women with overactive bladder syndrome (OAB) to see how it differs between those with and without a specific type of muscle overactivity during bladder tests. They found that the microbiomes of women with detrusor overactivity were less diverse compared to those without it and healthy controls, suggesting that the microbiome may play a role in the condition. This is important because understanding these differences could lead to new ways to treat OAB. Who this helps: Patients with overactive bladder syndrome.

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Researchers focused on creating safety guidelines for artificial joint replacement devices to make sure they perform well and protect patients. They used a structured process called the modified Delphi method, gathering input from experts across Europe, which resulted in 32 key recommendations. These guidelines help ensure that new orthopedic devices are safe and effective while fostering innovation within existing regulations. Who this helps: This benefits patients, orthopedic surgeons, and device manufacturers.

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This study looked at a new way to predict the risk of fractures in the thigh bone (femur) by using a special foam model that represents how bones behave under stress. Researchers tested this model with samples of actual human bone and found that it accurately predicted the strength and fracture points of the femur, achieving 79% to 90% accuracy compared to real-life tests. This matters because it can improve how doctors assess fracture risk in patients and better inform treatment decisions. Who this helps: Patients at risk for fractures, particularly older adults or those with osteoporosis.

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This study examined how a classification system from the American College of Medical Genetics and Genomics (ACMG) could improve the understanding of genetic test results for patients with factor VII deficiency, a rare bleeding disorder. Out of 129 patients, 35.5% of those with serious genetic variants (ACMG 5) experienced significant bleeding risks, compared to only 5% of patients with benign variants (ACMG 1-4). This research is important because it helps identify which patients are at higher risk for severe bleeding, allowing for better treatment planning. Who this helps: Patients with factor VII deficiency and their healthcare providers.

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This study compared the outcomes of two types of knee surgery: conventional total knee arthroplasty (CTKA) and NAVIO robotic-assisted surgery (NAVIO RATKA). The researchers found that while CTKA had a slightly shorter hospital stay (5.0 days vs. 5.4 days), both surgeries had similar rates of complications, readmissions, and drops in hemoglobin levels. However, NAVIO RATKA had different types of complications, such as more instances of persistent wound drainage (4.3% vs. 0.6%). Who this helps: This research benefits doctors and surgeons by providing insights on the safety and complications of knee surgery options.

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This study looked at whether certain birds, bats, and reptiles eat a specific pest called the leaf miner, which damages tomato plants. Researchers found that bats and several bird species, including partridges and swallows, consume these pests, as did lizards near the greenhouses. This is important because it shows that these animals play a role in controlling pests in tomato greenhouses, which can help farmers reduce damage to their crops. Who this helps: Farmers growing tomatoes.

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This study compared two methods of performing total knee surgery: a traditional approach using jigs and a new, handheld robotic system that doesn't rely on images. It involved 52 patients with knee osteoarthritis, and the results showed that the robotic system had a significantly lower number of alignment errors—only 5.8% compared to 24.4% for the traditional method. This matters because better implant placement can lead to improved recovery and functioning for patients after knee surgery. Who this helps: Patients undergoing knee replacement surgery.

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This study looked at how urinary tract infections (UTIs) affect the lives of patients with a condition called interstitial cystitis/bladder pain syndrome (IC/BPS). It found that over 50% of these patients experience UTIs, which can worsen their existing symptoms, and 70% worry about getting new infections. Additionally, many patients struggle to get diagnosed, with 70% of them facing delays because doctors often mistake their symptoms for UTIs, leading to increased healthcare visits and high levels of antibiotic resistance. Who this helps: This research benefits patients with IC/BPS and their healthcare providers by highlighting the need for better diagnosis and treatment guidelines.

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This study looked at how the medial patellofemoral ligament (MPFL) in healthy knees changes in length as the knee bends from straight (0°) to fully bent (90°). Researchers found that the MPFL length decreases by about 5 millimeters during this motion, with the upper part of the ligament getting shorter while the lower part gets tighter at deeper bending angles. Understanding these changes is important because incorrect placement during MPFL surgery can lead to complications if the graft is overstressed. Who this helps: This helps patients undergoing knee surgery, specifically those requiring MPFL reconstruction.

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This study looked at how adding a titanium layer to a knee implant made of PEEK affects its stability and interaction with bone. The researchers found that having a titanium inlay reduced the small movements at the implant site by 30% to 40%, with the most significant movements measured at 51.2 micrometers. This is important because reducing these movements can lead to better long-term stability of the implant without negatively affecting how the bone absorbs stress. Who this helps: This benefits patients receiving knee replacements and their surgeons.

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This study looked at how to improve health care for older adults in rural India by creating and testing a new assessment program that combines community and facility-based evaluations. Researchers designed and piloted this program, finding that it is feasible to implement and could lead to better health outcomes for older adults. This matters because it provides a practical way to integrate existing national policies into real-world care for the elderly, especially in low-middle-income countries. Who this helps: This helps older adults in India and the healthcare professionals providing their care.

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This study looked at whether a therapy called EMDR could help people with chronic obstructive pulmonary disease (COPD) who experience severe breathlessness and anxiety. Researchers worked with four patients who had three to five sessions of EMDR and found that three of them greatly improved their ability to cope with breathlessness, while one had a moderate improvement. Importantly, all the patients felt less anxious during episodes of breathlessness after the therapy, and they all recommended EMDR for others in similar situations. Who this helps: This helps COPD patients who struggle with anxiety related to their breathlessness.